You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta

Protein Summary
Description
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second me ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222254
  • ENSP00000222254
  • ENSG00000105647
  • ENST00000617130
  • ENSP00000477864

Symbol
  • p85
  • MPPH
  • P85B
  • MPPH1
  • p85-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
hub protein
0.98
interacting protein
0.97
pathway
0.91
transcription factor binding site profile
0.89


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.32   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 571   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.32   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 571   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphoinositide-3-kinase regulatory subunit 2
719367
Mouse
MGI:1098772
18709
Rat
RGD:68341
29741
Dog
phosphoinositide-3-kinase regulatory subunit 2
609956
Cow
phosphoinositide-3-kinase regulatory subunit 2
VGNC:52862
282308
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphoinositide-3-kinase regulatory subunit 2
Mouse
Rat
Dog
phosphoinositide-3-kinase regulatory subunit 2
Cow
phosphoinositide-3-kinase regulatory subunit 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (259)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 71
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Cell surface interactions at the vascular wall
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Cell surface interactions at the vascular wall
Gene Ontology Terms (31)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (472)
1 – 10 of 472
HAUS4
Tbio
Novelty: 0.91427982
p_int: 0.999199404
p_ni: 0.000800596
Data Source: BioPlex
RCBTB2
Tbio
Novelty: 0.04244536
p_int: 0.997078248
p_ni: 0.002921749
p_wrong: 3e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
PIK3R3
Tbio
Family: Enzyme
Novelty: 0.0136069
p_int: 0.990984064
p_ni: 0.009015936
Score: 0.982
Data Source: BioPlex,STRINGDB
HAUS1
Tbio
Novelty: 0.11356375
p_int: 0.974402783
p_ni: 0.025597032
p_wrong: 1.85e-7
Score: 0.204
Data Source: BioPlex,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
p_int: 0.965590096
p_ni: 0.034409904
Score: 0.983
Data Source: BioPlex,STRINGDB
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.95223554
p_ni: 0.04776446
Data Source: BioPlex
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.903752732
p_ni: 0.096247268
Data Source: BioPlex
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
p_int: 0.85797798
p_ni: 0.141833801
p_wrong: 0.00018822
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
TMEM52B
Tdark
Novelty: 1.55824039
p_int: 0.850635684
p_ni: 0.149364316
Score: 0.303
Data Source: BioPlex,STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.844517743
p_ni: 0.155482257
Score: 0.195
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  115.32

PubMed score by year
PubTator Score  373.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer