Tbio PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta

Protein Summary

Description

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• O00459
• Q5EAT5
• Q9UPH9
• PI3-kinase regulatory subunit beta

Gene Name

• PIK3R2

Ensembl ID

• ENST00000222254
• ENSP00000222254
• ENSG00000105647
• ENST00000617130
• ENSP00000477864

Symbol

• p85
• MPPH
• P85B
• MPPH1
• p85-BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
hub protein	0.98
interacting protein	0.97
pathway	0.91
transcription factor binding site profile	0.89

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Phosphatidylinositol 3-kinase Regulatory Subunit Beta

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Phosphatidylinositol 3-kinase Regulatory Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.62   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 571   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.62   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 571   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0