Tbio GFRA2 GDNF family receptor alpha-2

Protein Summary

Description

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• O00451
• E9PD47
• O15316
• O15328
• Q58J92
• Q6GTR9
• Q7Z5C2
• GDNF receptor alpha-2

Gene Name

• GFRA2

Ensembl ID

• ENST00000517328
• ENSP00000429445
• ENSG00000168546
• ENST00000517892
• ENSP00000429979
• ENST00000518077
• ENSP00000429206
• ENST00000524240
• ENSP00000428518

Symbol

• GDNFRB
• RETL2
• TRNR2
• NTNRA
• RETL2
• TRNR2
• GDNFRB
• NRTNR-ALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.68
disease	0.63
cell type or tissue	0.61
trait	0.61
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.98   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 345   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.98   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0