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Tbio
SYT5
Synaptotagmin-5

Protein Summary
Description
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354308
  • ENSP00000346265
  • ENSG00000129990
  • ENST00000537500
  • ENSP00000442896
  • ENST00000590851
  • ENSP00000465576
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
cellular component
0.8
cell type or tissue
0.69
molecular function
0.6
biological process
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.6   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.6   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
SYT1
Tbio
Novelty:  0.00176103
p_int:  1
Score:  0.364
Data Source:  BioPlex,STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.997118174
p_ni:  0.002881826
Score:  0.24
Data Source:  BioPlex,STRINGDB
PALM2
Tbio
Novelty:  0.03469098
p_int:  0.985811498
p_ni:  0.01379083
p_wrong:  0.000397672
Score:  0.325
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.978
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.967
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.966
Data Source:  STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.946
Data Source:  STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
Score:  0.932
Data Source:  STRINGDB
CACNA1D
Tclin
Family:  IC
Novelty:  0.00314752
Score:  0.927
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Integration of energy metabolism (R-HSA-163685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Regulation of insulin secretion
Name
Explore in Pharos
Explore in Source
Integration of energy metabolism
Metabolism
Regulation of insulin secretion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
4
5
90.3
mean corpuscular volume
1
3
3
87.5
platelet count
3
4
4
86.9
mean reticulocyte volume
1
1
1
77.1
monocyte count
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
5
90.3
mean corpuscular volume
3
87.5
platelet count
4
86.9
mean reticulocyte volume
1
77.1
monocyte count
1
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 5
VGNC:13528
100609218
Macaque
synaptotagmin 5
106994863
Mouse
MGI:1926368
53420
Rat
RGD:3806
54309
Dog
synaptotagmin 5
VGNC:47048
476382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 5
Macaque
synaptotagmin 5
Mouse
Rat
Dog
synaptotagmin 5
Publication Statistics
PubMed Score 22.60
PubMed score by year
PubTator Score 6.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title