Protein Summary
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
- ENST00000354308
- ENSP00000346265
- ENSG00000129990
- ENST00000537500
- ENSP00000442896
- ENST00000590851
- ENSP00000465576
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.99 | ||
cellular component | 0.8 | ||
cell type or tissue | 0.69 | ||
molecular function | 0.6 | ||
biological process | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.6 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 195 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.6 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 195 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
ATP6V1C2
Family: Enzyme
Novelty: 0.07583427
p_int: 0.997118174
p_ni: 0.002881826
Score: 0.24
Data Source: BioPlex,STRINGDB
PALM2
Novelty: 0.03469098
p_int: 0.985811498
p_ni: 0.01379083
p_wrong: 0.000397672
Score: 0.325
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Integration of energy metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Regulation of insulin secretion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Integration of energy metabolism | ||||
Metabolism | ||||
Regulation of insulin secretion | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (8)
Components (11)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 4 | 5 | 90.3 | |||||
mean corpuscular volume | 1 | 3 | 3 | 87.5 | |||||
platelet count | 3 | 4 | 4 | 86.9 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 77.1 | |||||
monocyte count | 1 | 1 | 1 | 67.4 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 5 | 90.3 | |||||
mean corpuscular volume | 3 | 87.5 | |||||
platelet count | 4 | 86.9 | |||||
mean reticulocyte volume | 1 | 77.1 | |||||
monocyte count | 1 | 67.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | synaptotagmin 5 | VGNC:13528 | 100609218 | |||||
Macaque | synaptotagmin 5 | 106994863 | ||||||
Mouse | MGI:1926368 | 53420 | ||||||
Rat | RGD:3806 | 54309 | ||||||
Dog | synaptotagmin 5 | VGNC:47048 | 476382 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | synaptotagmin 5 | |||||
Macaque | synaptotagmin 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | synaptotagmin 5 | |||||
Publication Statistics
PubMed Score 22.60
PubMed score by year
PubTator Score 6.26
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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