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Tchem
PIK3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Protein Summary
Description
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265970
  • ENSP00000265970
  • ENSG00000011405

Symbol
  • CPK
  • PI3-K-C2A
  • PI3K-C2alpha
  • PI3K-C2-alpha
  • PI3-K-C2(ALPHA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
drug perturbation
0.96
molecular function
0.96
kinase perturbation
0.93
co-expressed gene
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4496.4   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4496.4   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1765602
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1
50.4
platelet count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1
50.4
platelet count
1
30.2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Metabolism
Metabolism of lipids
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (281)
1 – 10 of 281
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999998986
p_ni: 0.000001014
Score: 0.795
Data Source: BioPlex,STRINGDB
FAM136A
Tdark
Novelty: 0.4050275
p_int: 0.999996979
p_ni: 0.000003021
Data Source: BioPlex
CLINT1
Tbio
Novelty: 0.00945381
p_int: 0.999963174
p_ni: 0.000036826
Score: 0.986
Data Source: BioPlex,STRINGDB
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.99991797
p_ni: 0.00008203
Score: 0.659
Data Source: BioPlex,STRINGDB
PICALM
Tbio
Novelty: 0.00800832
p_int: 0.99986396
p_ni: 0.000136033
p_wrong: 6e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
EIF5A2
Tbio
Novelty: 0.01527502
p_int: 0.999842883
p_ni: 0.000157056
p_wrong: 6.1e-8
Data Source: BioPlex
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.992959528
p_ni: 0.007040472
Score: 0.202
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.983888726
p_ni: 0.016111273
p_wrong: 2e-9
Score: 0.208
Data Source: BioPlex,STRINGDB
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.948865312
p_ni: 0.051134687
p_wrong: 1e-9
Data Source: BioPlex
CRYL1
Tbio
Family: Enzyme
Novelty: 0.04513297
p_int: 0.936876521
p_ni: 0.063123478
Data Source: BioPlex
Publication Statistics
PubMed Score  4496.40

PubMed score by year
PubTator Score  1191.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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