Protein Summary
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neu ...more
- ENST00000266481
- ENSP00000266481
- ENSG00000087470
- ENST00000381000
- ENSP00000370388
- ENST00000414834
- ENSP00000404160
- ENST00000452533
- ENSP00000415131
- ENST00000547312
- ENSP00000448610
- ENST00000549701
- ENSP00000450399
- ENST00000553257
- ENSP00000449089
- DLP1
- DRP1
- DLP1
- DRP1
- DVLP
- EMPF
- OPA5
- EMPF1
- DYMPLE
- HDYNIV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
molecular function | 0.98 | ||
protein domain | 0.97 | ||
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 841.12 (req: < 5)
Gene RIFs: 162 (req: <= 3)
Antibodies: 580 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 841.12 (req: >= 5)
Gene RIFs: 162 (req: > 3)
Antibodies: 580 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (214)
CPNE2
Novelty: 0.24188419
p_int: 0.999997296
p_ni: 0.000002704
Score: 0.159
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.99981869
p_ni: 0.000181244
p_wrong: 6.7e-8
Data Source: BioPlex
JTB
Novelty: 0.06646216
p_int: 0.997861319
p_ni: 0.00213787
p_wrong: 8.12e-7
Data Source: BioPlex
CA14
Family: Enzyme
Novelty: 0.00864764
p_int: 0.996576656
p_ni: 0.003226159
p_wrong: 0.000197185
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.995801917
p_ni: 0.004198082
p_wrong: 1e-9
Data Source: BioPlex
FGL1
Novelty: 0.02650803
p_int: 0.99537157
p_ni: 0.004628384
p_wrong: 4.6e-8
Data Source: BioPlex
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.985328318
p_ni: 0.014522653
p_wrong: 0.000149029
Score: 0.194
Data Source: BioPlex,STRINGDB
HAX1
Novelty: 0.00749205
p_int: 0.979649932
p_ni: 0.020349974
p_wrong: 9.4e-8
Score: 0.215
Data Source: BioPlex,STRINGDB
CYB5B
Novelty: 0.09395308
p_int: 0.965333197
p_ni: 0.034666655
p_wrong: 1.48e-7
Score: 0.303
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (7)
Reactome (3)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Programmed Cell Death | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Apoptosis | ||||
Apoptotic execution phase | ||||
Programmed Cell Death | ||||
Viral Interactions (0)
Gene Ontology Terms (71)
Functions (13)
Components (21)
Processes (37)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred by Curator (IC) | ParkinsonsUK-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 3 | 94.8 | |||||
3 | 2 | 0 | 1.1 | 78.2 | |||||
platelet count | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 94.8 | |||||
0 | 1.1 | 78.2 | |||||
platelet count | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dynamin 1 like | VGNC:13030 | 465266 | |||||
Macaque | dynamin 1 like | 695388 | ||||||
Mouse | MGI:1921256 | 74006 | ||||||
Rat | RGD:620416 | 114114 | ||||||
Dog | dynamin 1 like | VGNC:40032 | 477649 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dynamin 1 like | |||||
Macaque | dynamin 1 like | |||||
Mouse | ||||||
Rat | ||||||
Dog | dynamin 1 like | |||||
Publication Statistics
PubMed Score 841.12
PubMed score by year
PubTator Score 320.88
PubTator score by year
Related Publications
Text Mined References (207)
GeneRif Annotations (162)
Items per page:
0 of 0
PMID | Year | Title |
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