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Tbio
IGF2BP3
Insulin-like growth factor 2 mRNA-binding protein 3

Protein Classes
Protein Summary
Description
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudoge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258729
  • ENSP00000258729
  • ENSG00000136231
  • ENST00000619562
  • ENSP00000480267

Symbol
  • IMP3
  • KOC1
  • VICKZ3
  • KOC
  • CT98
  • IMP3
  • KOC1
  • IMP-3
  • VICKZ3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
transcription factor binding site profile
0.95
PubMedID
0.94
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.99   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.99   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
5
3
5
92.5
2
2
1
1.1
71
body height
1
1
1
66.2
1
1
0
1.1
55.9
body height at birth
1
1
1
46.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
5
92.5
1
1.1
71
body height
1
66.2
0
1.1
55.9
body height at birth
1
46.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor 2 mRNA binding protein 3
VGNC:4396
744246
Macaque
insulin like growth factor 2 mRNA binding protein 3
704774
Mouse
MGI:1890359
140488
Dog
insulin like growth factor 2 mRNA binding protein 3
VGNC:41900
482357
Horse
insulin like growth factor 2 mRNA binding protein 3
VGNC:18971
100067926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor 2 mRNA binding protein 3
Macaque
insulin like growth factor 2 mRNA binding protein 3
Mouse
Dog
insulin like growth factor 2 mRNA binding protein 3
Horse
insulin like growth factor 2 mRNA binding protein 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00425-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA (R-HSA-428359)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Metabolism of RNA
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (52)
1 – 10 of 52
SH3BGR
Tbio
Novelty: 0.19912265
p_int: 0.967509573
p_ni: 0.032490427
Score: 0.309
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.956706174
p_ni: 0.043293826
Score: 0.655
Data Source: BioPlex,STRINGDB
GSPT2
Tbio
Family: Enzyme
Novelty: 0.08140512
p_int: 0.954177106
p_ni: 0.045822894
Score: 0.239
Data Source: BioPlex,STRINGDB
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.946443972
p_ni: 0.053556028
Data Source: BioPlex
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.889557739
p_ni: 0.110442261
Data Source: BioPlex
RPL23A
Tbio
Novelty: 0.02951947
p_int: 0.883586987
p_ni: 0.116413013
Data Source: BioPlex
RBM47
Tbio
Novelty: 0.04787234
p_int: 0.880753055
p_ni: 0.119246945
Score: 0.268
Data Source: BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty: 0.01125284
p_int: 0.879255302
p_ni: 0.120744698
Data Source: BioPlex
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.874786842
p_ni: 0.125213157
Data Source: BioPlex
ILF2
Tbio
Novelty: 0.01598188
p_int: 0.868643275
p_ni: 0.131356725
Score: 0.303
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  133.99

PubMed score by year
PubTator Score  95.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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