Tbio IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3

Protein Summary

Description

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00425
• A0A4Z5
• Q63HM0
• Q6MZZ2
• Q86VB1
• IGF2 mRNA-binding protein 3

Gene Name

• IGF2BP3

Ensembl ID

• ENST00000258729
• ENSP00000258729
• ENSG00000136231
• ENST00000619562
• ENSP00000480267

Symbol

• IMP3
• KOC1
• VICKZ3
• KOC
• CT98
• IMP3
• KOC1
• IMP-3
• VICKZ3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	1
transcription factor binding site profile	0.95
PubMedID	0.94
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Insulin-like Growth Factor 2 Mrna-binding Protein 3

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Insulin-like Growth Factor 2 Mrna-binding Protein 3

Protein / Enzyme Modulator / Insulin-like Growth Factor 2 Mrna-binding Protein 3

Protein / ... / Serine Protease / Insulin-like Growth Factor 2 Mrna-binding Protein 3

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Insulin-like Growth Factor 2 Mrna-binding Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.18   (req: < 5)

Gene RIFs: 240   (req: <= 3)

Antibodies: 334   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.18   (req: >= 5)

Gene RIFs: 240   (req: > 3)

Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0