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Tbio
SAP18
Histone deacetylase complex subunit SAP18

Protein Summary
Description
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. In ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607003
  • ENSP00000475925
  • ENSG00000150459

Symbol
  • SAP18P
  • 2HOR0202
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.97
kinase perturbation
0.93
virus perturbation
0.88
protein complex
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.02   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.02   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sin3A associated protein 18
VGNC:5106
452467
Macaque
Sin3A associated protein 18
703078
Mouse
MGI:1277978
20220
Mouse
MGI:3704317
100041953
Rat
RGD:1561590
498002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sin3A associated protein 18
Macaque
Sin3A associated protein 18
Mouse
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00422-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
HDACs deacetylate histones
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (257)
1 – 10 of 257
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
p_int: 0.999999435
p_ni: 5.61e-7
p_wrong: 4e-9
Data Source: BioPlex
ZC3H13
Tbio
Novelty: 0.0990341
p_int: 0.999998022
p_ni: 0.000001978
Data Source: BioPlex
ACIN1
Tbio
Novelty: 0.01675479
p_int: 0.999987858
p_ni: 0.000012141
Score: 0.998
Data Source: BioPlex,STRINGDB
PRPF38B
Tdark
Novelty: 1.02626586
p_int: 0.999987092
p_ni: 0.000002883
p_wrong: 0.000010025
Data Source: BioPlex
RNPS1
Tbio
Novelty: 0.03203224
p_int: 0.999979229
p_ni: 0.000020771
Score: 0.997
Data Source: BioPlex,STRINGDB
PRPF40A
Tbio
Novelty: 0.00898047
p_int: 0.999946751
p_ni: 0.00005325
Score: 0.262
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.01395394
p_int: 0.999893839
p_ni: 0.000106161
Score: 0.976
Data Source: BioPlex,STRINGDB
PHRF1
Tbio
Family: Epigenetic
Novelty: 0.05250013
p_int: 0.99974563
p_ni: 0.00012802
p_wrong: 0.00012635
Data Source: BioPlex
VIRMA
Tbio
Novelty: 0.05400878
p_int: 0.999718897
p_ni: 0.00027998
p_wrong: 0.000001123
Data Source: BioPlex
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.99962935
p_ni: 0.000370649
Data Source: BioPlex
Publication Statistics
PubMed Score  21.02

PubMed score by year
PubTator Score  12.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer