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Tbio
POLRMT
DNA-directed RNA polymerase, mitochondrial

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000588649
  • ENSP00000465759
  • ENSG00000099821

Symbol
  • APOLMT
  • MTRNAP
  • MTRPOL
  • h-mtRPOL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
histone modification site profile
0.79
disease perturbation
0.68
transcription factor perturbation
0.68
tissue sample
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.68   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.68   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915843
216151
Rat
RGD:1304599
299604
Cow
RNA polymerase mitochondrial
VGNC:33154
504757
Opossum
RNA polymerase mitochondrial
100024662
Chicken
RNA polymerase mitochondrial
CGNC:944
420084
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
RNA polymerase mitochondrial
Opossum
RNA polymerase mitochondrial
Chicken
RNA polymerase mitochondrial
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00411-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial transcription initiation
Reactome
Organelle biogenesis and maintenance
Reactome
Transcription from mitochondrial promoters
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Mitochondrial biogenesis
Mitochondrial transcription initiation
Organelle biogenesis and maintenance
Transcription from mitochondrial promoters
Protein-Protein Interactions (127)
1 – 10 of 127
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.999954025
p_ni: 0.000045975
Score: 0.162
Data Source: BioPlex,STRINGDB
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.999909945
p_ni: 0.000090055
Score: 0.171
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.99983615
p_ni: 0.00016385
Score: 0.915
Data Source: BioPlex,STRINGDB
NELL2
Tbio
Family: Enzyme
Novelty: 0.03760438
p_int: 0.99861692
p_ni: 0.00138308
Data Source: BioPlex
NELL1
Tbio
Family: Enzyme
Novelty: 0.01325888
p_int: 0.989269997
p_ni: 0.010730003
Data Source: BioPlex
CLEC11A
Tbio
Novelty: 0.03060601
p_int: 0.97532658
p_ni: 0.02467342
Data Source: BioPlex
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.964819807
p_ni: 0.035180193
Score: 0.53
Data Source: BioPlex,STRINGDB
VWCE
Tbio
Novelty: 0.09328341
p_int: 0.963524184
p_ni: 0.036475816
Data Source: BioPlex
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.956635097
p_ni: 0.043364903
Data Source: BioPlex
TRIM10
Tbio
Novelty: 0.27685659
p_int: 0.950765914
p_ni: 0.049234086
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  78.68

PubMed score by year
PubTator Score  39.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer