Tbio POLRMT DNA-directed RNA polymerase, mitochondrial

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00411
• O60370
• MtRPOL

Gene Name

• POLRMT

Ensembl ID

• ENST00000588649
• ENSP00000465759
• ENSG00000099821

Symbol

• APOLMT
• MTRNAP
• MTRPOL
• h-mtRPOL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
histone modification site profile	0.79
disease perturbation	0.68
transcription factor perturbation	0.68
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerase, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.43   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.43   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0