Tbio POLRMT DNA-directed RNA polymerase, mitochondrial

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00411
• O60370
• MtRPOL

Gene Name

• POLRMT

Ensembl ID

• ENST00000588649
• ENSP00000465759
• ENSG00000099821

Symbol

• APOLMT
• MTRNAP
• MTRPOL
• h-mtRPOL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
histone modification site profile	0.79
disease perturbation	0.68
transcription factor perturbation	0.68
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerase, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.51   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.51   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (127)

Explore Interacting Targets

1 – 10 of 127

• See Interactions on String-DB

PPP6R2

Tbio

Family:  Enzyme

Novelty:  0.12886225

p_int:  0.999954025

p_ni:  0.000045975

Score:  0.162

Data Source:  BioPlex,STRINGDB

KCTD17

Tbio

Novelty:  0.12105733

p_int:  0.999909945

p_ni:  0.000090055

Score:  0.171

Data Source:  BioPlex,STRINGDB

MRPL12

Tbio

Novelty:  0.10646542

p_int:  0.99983615

p_ni:  0.00016385

Score:  0.915

Data Source:  BioPlex,STRINGDB

NELL2

Tbio

Family:  Enzyme

Novelty:  0.03760438

p_int:  0.99861692

p_ni:  0.00138308

Data Source:  BioPlex

NELL1

Tbio

Family:  Enzyme

Novelty:  0.01325888

p_int:  0.989269997

p_ni:  0.010730003

Data Source:  BioPlex

CLEC11A

Tbio

Novelty:  0.03060601

p_int:  0.97532658

p_ni:  0.02467342

Data Source:  BioPlex

MRPS17

Tdark

Novelty:  0.46103276

p_int:  0.964819807

p_ni:  0.035180193

Score:  0.53

Data Source:  BioPlex,STRINGDB

VWCE

Tbio

Novelty:  0.09328341

p_int:  0.963524184

p_ni:  0.036475816

Data Source:  BioPlex

P4HA1

Tchem

Family:  Enzyme

Novelty:  0.01624726

p_int:  0.956635097

p_ni:  0.043364903

Data Source:  BioPlex

TRIM10

Tbio

Novelty:  0.27685659

p_int:  0.950765914

p_ni:  0.049234086

Score:  0.179

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (19)

Reactome (6)

WikiPathways (13)

Gene expression (Transcription) (R-HSA-74160)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Mitochondrial biogenesis	89 targets	R-HSA-1592230
Reactome	Mitochondrial transcription initiation	3 targets	R-HSA-163282
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241
Reactome	Transcription from mitochondrial promoters	4 targets	R-HSA-75944

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Mitochondrial biogenesis	89 targets	R-HSA-1592230
Mitochondrial transcription initiation	3 targets	R-HSA-163282
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241
Transcription from mitochondrial promoters	4 targets	R-HSA-75944

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (5)

Processes (3)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA-directed 5'-3' RNA polymerase activity	Inferred from Direct Assay (IDA)	UniProtKB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
mitochondrial promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3	2	3		41.9
worry measurement	EFO_0009589	1	1	1		33.1
cognitive function measurement	EFO_0008354	2	1	2		31.4
mathematical ability	EFO_0004875	1	1	1		21.5
pulse pressure measurement	EFO_0005763	1	1	1		14

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3		41.9
worry measurement	EFO_0009589	1		33.1
cognitive function measurement	EFO_0008354	2		31.4
mathematical ability	EFO_0004875	1		21.5
pulse pressure measurement	EFO_0005763	1		14

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
DNA-directed RNA polymerase
Mitochondrion
Nucleotidyltransferase
Polymorphism
Reference proteome
Transcription
Transferase
Transit peptide

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
mathematical ability
pulse pressure measurement
sex hormone-binding globulin measurement
worry measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
mortality/aging
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	polymerase (RNA) mitochondrial (DNA directed)	MGI:1915843	216151
Rat	RNA polymerase mitochondrial	RGD:1304599	299604
Cow	RNA polymerase mitochondrial	VGNC:33154	504757
Opossum	RNA polymerase mitochondrial		100024662
Chicken	RNA polymerase mitochondrial	CGNC:944	420084

Species	Name	OMA	EggNOG	Inparanoid
Mouse	polymerase (RNA) mitochondrial (DNA directed)
Rat	RNA polymerase mitochondrial
Cow	RNA polymerase mitochondrial
Opossum	RNA polymerase mitochondrial
Chicken	RNA polymerase mitochondrial

Publication Statistics

PubMed Score 80.51

PubMed score by year

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PubTator Score 39.09

PubTator score by year

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Related Publications

Text Mined References (33)

GeneRif Annotations (19)

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10

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PMID	Year	Title