POLRMT
DNA-directed RNA polymerase, mitochondrial
Protein Classes
Protein Summary
DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
- ENST00000588649
- ENSP00000465759
- ENSG00000099821
- APOLMT
- MTRNAP
- MTRPOL
- h-mtRPOL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.95 | ||
histone modification site profile | 0.79 | ||
disease perturbation | 0.68 | ||
transcription factor perturbation | 0.68 | ||
tissue sample | 0.62 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 78.68 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 91 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 78.68 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 91 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1915843 | 216151 | ||||||
Rat | RGD:1304599 | 299604 | ||||||
Cow | RNA polymerase mitochondrial | VGNC:33154 | 504757 | |||||
Opossum | RNA polymerase mitochondrial | 100024662 | ||||||
Chicken | RNA polymerase mitochondrial | CGNC:944 | 420084 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Cow | RNA polymerase mitochondrial | |||||
Opossum | RNA polymerase mitochondrial | |||||
Chicken | RNA polymerase mitochondrial | |||||
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (19)
Reactome (6)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Mitochondrial biogenesis | ||||
Reactome | Mitochondrial transcription initiation | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Transcription from mitochondrial promoters | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Mitochondrial biogenesis | ||||
Mitochondrial transcription initiation | ||||
Organelle biogenesis and maintenance | ||||
Transcription from mitochondrial promoters | ||||
Gene Ontology Terms (12)
Functions (4)
Components (5)
Processes (3)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (127)
1 – 10 of 127
PPP6R2
Family: Enzyme
Novelty: 0.12886225
p_int: 0.999954025
p_ni: 0.000045975
Score: 0.162
Data Source: BioPlex,STRINGDB
KCTD17
Novelty: 0.12105733
p_int: 0.999909945
p_ni: 0.000090055
Score: 0.171
Data Source: BioPlex,STRINGDB
MRPL12
Novelty: 0.10646542
p_int: 0.99983615
p_ni: 0.00016385
Score: 0.915
Data Source: BioPlex,STRINGDB
NELL2
Family: Enzyme
Novelty: 0.03760438
p_int: 0.99861692
p_ni: 0.00138308
Data Source: BioPlex
NELL1
Family: Enzyme
Novelty: 0.01325888
p_int: 0.989269997
p_ni: 0.010730003
Data Source: BioPlex
CLEC11A
Novelty: 0.03060601
p_int: 0.97532658
p_ni: 0.02467342
Data Source: BioPlex
MRPS17
Novelty: 0.46103276
p_int: 0.964819807
p_ni: 0.035180193
Score: 0.53
Data Source: BioPlex,STRINGDB
VWCE
Novelty: 0.09328341
p_int: 0.963524184
p_ni: 0.036475816
Data Source: BioPlex
P4HA1
Family: Enzyme
Novelty: 0.01624726
p_int: 0.956635097
p_ni: 0.043364903
Data Source: BioPlex
TRIM10
Novelty: 0.27685659
p_int: 0.950765914
p_ni: 0.049234086
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 78.68
PubMed score by year
PubTator Score 39.09
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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