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Tbio
IPO5
Importin-5

Protein Summary
Description
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261574
  • ENSP00000261574
  • ENSG00000065150
  • ENST00000357602
  • ENSP00000350219
  • ENST00000490680
  • ENSP00000418393

Symbol
  • KPNB3
  • RANBP5
  • IMB3
  • Pse1
  • imp5
  • KPNB3
  • RANBP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
kinase perturbation
0.96
virus perturbation
0.95
hub protein
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.75   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.75   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (234)
1 – 10 of 234
MRPL34
Tdark
Novelty:  1.17388411
p_int:  0.999966928
p_ni:  0.000033069
p_wrong:  3e-9
Score:  0.562
Data Source:  BioPlex,STRINGDB
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.999002842
p_ni:  0.000997158
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.995949635
p_ni:  0.004050365
Data Source:  BioPlex
AVPI1
Tdark
Novelty:  0.28472403
p_int:  0.992701032
p_ni:  0.007298968
Data Source:  BioPlex
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
p_int:  0.964729206
p_ni:  0.035270794
Score:  0.431
Data Source:  BioPlex,STRINGDB
NOL7
Tbio
Novelty:  0.24085052
p_int:  0.898556015
p_ni:  0.101443985
Score:  0.308
Data Source:  BioPlex,STRINGDB
MRPL35
Tdark
Novelty:  0.30867276
p_int:  0.859812821
p_ni:  0.140187179
Score:  0.217
Data Source:  BioPlex,STRINGDB
RPL13
Tbio
Novelty:  0.0159486
p_int:  0.831619657
p_ni:  0.168380343
Score:  0.46
Data Source:  BioPlex,STRINGDB
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.821512113
p_ni:  0.178487887
Data Source:  BioPlex
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.814489218
p_ni:  0.185510782
Score:  0.151
Data Source:  BioPlex,STRINGDB
Pathways (6)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Influenza Infection
Reactome
Influenza Life Cycle
Reactome
Influenza Viral RNA Transcription and Replication
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Influenza Infection
Influenza Life Cycle
Influenza Viral RNA Transcription and Replication
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
importin 5
VGNC:5069
739518
Macaque
importin 5
697448
Mouse
MGI:1917822
70572
Rat
RGD:1308715
306182
Dog
importin 5
VGNC:42066
485528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
importin 5
Macaque
importin 5
Mouse
Rat
Dog
importin 5
Publication Statistics
PubMed Score 218.75
PubMed score by year
PubTator Score 42.56
PubTator score by year