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Tclin
PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027). Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334456
  • ENSP00000334910
  • ENSG00000186642
  • ENST00000376450
  • ENSP00000365633
  • ENST00000444035
  • ENSP00000411657
  • ENST00000540345
  • ENSP00000446399
  • ENST00000544570
  • ENSP00000442256

Symbol
  • PDE2A1
  • PED2A4
  • cGSPDE
  • CGS-PDE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
0.85
PubMedID
0.82
gene perturbation
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.37   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.37   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 481
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
dipyridamole
chemical structure image
milrinone
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
6
3
6
98.7
self reported educational attainment
2
2
2
97.1
insomnia measurement
1
2
0
1.1
78.1
heel bone mineral density
1
1
1
55.4
1
1
0
1.1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
6
98.7
self reported educational attainment
2
97.1
insomnia measurement
0
1.1
78.1
heel bone mineral density
1
55.4
0
1.1
52.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 2A
VGNC:3074
451405
Macaque
phosphodiesterase 2A
718479
Rat
RGD:620965
81743
Dog
phosphodiesterase 2A
VGNC:44351
609574
Horse
phosphodiesterase 2A
VGNC:21242
100052619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 2A
Macaque
phosphodiesterase 2A
Rat
Dog
phosphodiesterase 2A
Horse
phosphodiesterase 2A
Protein Structure (38 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00408-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 38
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (95)
1 – 10 of 95
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999802911
p_ni: 0.000001464
p_wrong: 0.000195625
Score: 0.189
Data Source: BioPlex,STRINGDB
PDE6G
Tclin
Family: Enzyme
Novelty: 0.03113994
Score: 0.973
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.915
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.909
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.906
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.905
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.903
Data Source: STRINGDB
PDE5A
Tclin
Family: Enzyme
Novelty: 0.00032205
Score: 0.864
Data Source: STRINGDB
ADCY10
Tchem
Family: Enzyme
Novelty: 0.00037654
Score: 0.84
Data Source: STRINGDB
GUCY1A2
Tclin
Family: Enzyme
Novelty: 0.05335767
Score: 0.832
Data Source: STRINGDB
Publication Statistics
PubMed Score  118.37

PubMed score by year
PubTator Score  43.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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