PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase
Protein Summary
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027). Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).
- ENST00000334456
- ENSP00000334910
- ENSG00000186642
- ENST00000376450
- ENSP00000365633
- ENST00000444035
- ENSP00000411657
- ENST00000540345
- ENSP00000446399
- ENST00000544570
- ENSP00000442256
- PDE2A1
- PED2A4
- cGSPDE
- CGS-PDE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
protein domain | 0.85 | ||
PubMedID | 0.82 | ||
gene perturbation | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 122.54 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 292 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 122.54 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 292 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 716
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2