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Tbio
WASL
Neural Wiskott-Aldrich syndrome protein

Protein Summary
Description
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). This gene encodes a member of the Wiskott-Aldrich syndrome ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223023
  • ENSP00000223023
  • ENSG00000106299

Symbol
  • NWASP
  • WASPB
  • N-WASP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
transcription factor binding site profile
0.93
protein domain
0.85
interacting protein
0.83
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.08   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.08   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
29.6
reticulocyte count
2
1
2
24.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
29.6
reticulocyte count
2
24.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wiskott-Aldrich syndrome like
VGNC:8789
463688
Macaque
Wiskott-Aldrich syndrome like
696556
Mouse
MGI:1920428
73178
Dog
Wiskott-Aldrich syndrome like
475213
Horse
Wiskott-Aldrich syndrome like
100071546
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wiskott-Aldrich syndrome like
Macaque
Wiskott-Aldrich syndrome like
Mouse
Dog
Wiskott-Aldrich syndrome like
Horse
Wiskott-Aldrich syndrome like
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00401-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (85)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell-Cell communication
Reactome
Clathrin-mediated endocytosis
Reactome
DCC mediated attractive signaling
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell-Cell communication
Clathrin-mediated endocytosis
DCC mediated attractive signaling
Developmental Biology
Gene Ontology Terms (40)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (375)
1 – 10 of 375
NCK2
Tbio
Novelty: 0.02220251
p_int: 1
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999999997
p_ni: 3e-9
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.99999999
p_ni: 1e-8
Score: 0.852
Data Source: BioPlex,Reactome,STRINGDB
WIPF2
Tbio
Novelty: 0.11973409
p_int: 0.999999985
p_ni: 1.4e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
WIPF3
Tdark
Novelty: 0.0257625
p_int: 0.999999348
p_ni: 2e-9
p_wrong: 6.5e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
WIPF1
Tbio
Novelty: 0.00427982
p_int: 0.99999906
p_ni: 2e-9
p_wrong: 9.38e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ATG4C
Tbio
Family: Enzyme
Novelty: 0.04175533
p_int: 0.999950059
p_ni: 0.000041955
p_wrong: 0.000007986
Score: 0.199
Data Source: BioPlex,STRINGDB
ARHGAP12
Tbio
Family: Enzyme
Novelty: 0.12113722
p_int: 0.999269416
p_ni: 0.00067837
p_wrong: 0.000052214
Score: 0.85
Data Source: BioPlex,STRINGDB
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.950613747
p_ni: 0.02158992
p_wrong: 0.027796333
Data Source: BioPlex
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.925633457
p_ni: 0.074366543
Score: 0.465
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  344.08

PubMed score by year
PubTator Score  183.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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