Tbio WASL Neural Wiskott-Aldrich syndrome protein

Protein Summary

Description

Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O00401
• A1JUI9
• Q7Z746
• N-WASP

Gene Name

• WASL

Ensembl ID

• ENST00000223023
• ENSP00000223023
• ENSG00000106299

Symbol

• NWASP
• WASPB
• N-WASP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
transcription factor binding site profile	0.93
protein domain	0.85
interacting protein	0.83
hub protein	0.79

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Neural Wiskott-aldrich Syndrome Protein

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Neural Wiskott-aldrich Syndrome Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.6   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.6   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (375)

Explore Interacting Targets

1 – 10 of 375

• See Interactions on String-DB

NCK2

Tbio

Novelty:  0.02220251

p_int:  1

Score:  0.987

Data Source:  BioPlex,Reactome,STRINGDB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.999999997

p_ni:  3e-9

Score:  0.992

Data Source:  BioPlex,Reactome,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.99999999

p_ni:  1e-8

Score:  0.852

Data Source:  BioPlex,Reactome,STRINGDB

WIPF2

Tbio

Novelty:  0.11973409

p_int:  0.999999985

p_ni:  1.4e-8

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

WIPF3

Tdark

Novelty:  0.0257625

p_int:  0.999999348

p_ni:  2e-9

p_wrong:  6.5e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

WIPF1

Tbio

Novelty:  0.00427982

p_int:  0.99999906

p_ni:  2e-9

p_wrong:  9.38e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ATG4C

Tbio

Family:  Enzyme

Novelty:  0.04175533

p_int:  0.999950059

p_ni:  0.000041955

p_wrong:  0.000007986

Score:  0.199

Data Source:  BioPlex,STRINGDB

ARHGAP12

Tbio

Family:  Enzyme

Novelty:  0.12113722

p_int:  0.999269416

p_ni:  0.00067837

p_wrong:  0.000052214

Score:  0.85

Data Source:  BioPlex,STRINGDB

BCHE

Tclin

Family:  Enzyme

Novelty:  0.00031267

p_int:  0.950613747

p_ni:  0.02158992

p_wrong:  0.027796333

Data Source:  BioPlex

ACTBL2

Tbio

Novelty:  0.18080702

p_int:  0.925633457

p_ni:  0.074366543

Score:  0.465

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (1)

1 – 2 of 2

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  3

1: Yersinia infection

2: Regulation of actin cytoskeleton

3: Bacterial invasion of epithelial cells

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  3

1: Yersinia infection

2: Regulation of actin cytoskeleton

3: Bacterial invasion of epithelial cells

Pathways (85)

Reactome (22)

KEGG (8)

PathwayCommons (11)

WikiPathways (44)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	DCC mediated attractive signaling	14 targets	R-HSA-418885
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cell-Cell communication	121 targets	R-HSA-1500931
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
DCC mediated attractive signaling	14 targets	R-HSA-418885
Developmental Biology	1055 targets	R-HSA-1266738

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (40)

Functions (2)

Components (11)

Processes (27)

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1 – 2 of 2

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase regulator activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	3	5	4	4.1	97.5
platelet crit	EFO_0007985	2	4	4		95.3
mean platelet volume	EFO_0004584	3	4	4		93.6
reticulocyte count	EFO_0007986	4	5	6		91.4
reticulocyte measurement	EFO_0010700	2	3	4		84.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	4	4.1	97.5
platelet crit	EFO_0007985	4		95.3
mean platelet volume	EFO_0004584	4		93.6
reticulocyte count	EFO_0007986	6		91.4
reticulocyte measurement	EFO_0010700	4		84.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Actin-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Methylation
Mitosis

GWAS Trait Find Similar Targets

No Header	No Header
HbA1c measurement
mean corpuscular volume
mean platelet volume
platelet count
platelet crit
reticulocyte count
reticulocyte measurement
sleep apnea measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Wiskott-Aldrich syndrome like	VGNC:8789	463688
Macaque	Wiskott-Aldrich syndrome like		696556
Mouse	Wiskott-Aldrich syndrome-like (human)	MGI:1920428	73178
Dog	Wiskott-Aldrich syndrome like		475213
Horse	Wiskott-Aldrich syndrome like		100071546

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Wiskott-Aldrich syndrome like
Macaque	Wiskott-Aldrich syndrome like
Mouse	Wiskott-Aldrich syndrome-like (human)
Dog	Wiskott-Aldrich syndrome like
Horse	Wiskott-Aldrich syndrome like

Publication Statistics

PubMed Score 346.60

PubMed score by year

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PubTator Score 183.45

PubTator score by year

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Related Publications

Text Mined References (119)

GeneRif Annotations (52)

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PMID	Year	Title