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Tdark
DCTN6
Dynactin subunit 6

Protein Summary
Description
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221114
  • ENSP00000221114
  • ENSG00000104671

Symbol
  • WS3
  • WS3
  • p27
  • WS-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.92
transcription factor binding site profile
0.88
disease perturbation
0.83
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (221)
1 – 10 of 221
ACTR1B
Tbio
Novelty: 0.10014723
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
p_int: 0.99999926
p_ni: 7.4e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR10
Tbio
Novelty: 0.11388846
p_int: 0.999999089
p_ni: 9.1e-7
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.999996447
p_ni: 0.000003553
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
DCTN5
Tdark
Novelty: 0.19530162
p_int: 0.999994706
p_ni: 0.000005292
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ZBTB43
Tdark
Family: TF
Novelty: 0.35735342
p_int: 0.999970633
p_ni: 0.000029346
p_wrong: 2.2e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
DCTN4
Tbio
Novelty: 0.10319227
p_int: 0.999969722
p_ni: 0.000030278
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR1A
Tbio
Novelty: 0.06306209
p_int: 0.999941174
p_ni: 0.000058826
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.999843615
p_ni: 0.000156385
Score: 0.377
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.85

PubMed score by year
PubTator Score  362.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer