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Tbio
QSOX1
Sulfhydryl oxidase 1

Protein Summary
Description
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation. This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367600
  • ENSP00000356572
  • ENSG00000116260
  • ENST00000367602
  • ENSP00000356574

Symbol
  • QSCN6
  • Q6
  • QSCN6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.83
histone modification site profile
0.81
cellular component
0.69
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.25   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.25   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
47.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
47.4
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Protein-Protein Interactions (289)
1 – 10 of 289
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999890509
p_ni: 0.000109489
p_wrong: 2e-9
Data Source: BioPlex
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.999621986
p_ni: 0.000378014
Data Source: BioPlex
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.999453408
p_ni: 0.000546591
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
CRP
Tbio
Novelty: 0.00001517
p_int: 0.998767534
p_ni: 0.001232412
p_wrong: 5.4e-8
Data Source: BioPlex
FIS1
Tbio
Novelty: 0.0033607
p_int: 0.997459187
p_ni: 0.00253305
p_wrong: 0.000007763
Data Source: BioPlex
ENSA
Tbio
Novelty: 0.01642444
p_int: 0.996501465
p_ni: 0.003498514
p_wrong: 2.1e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
GLT8D2
Tbio
Family: Enzyme
Novelty: 0.79488367
p_int: 0.994746019
p_ni: 0.003266692
p_wrong: 0.001987289
Score: 0.201
Data Source: BioPlex,STRINGDB
TEFM
Tbio
Novelty: 0.10836617
p_int: 0.991931456
p_ni: 0.007363764
p_wrong: 0.00070478
Data Source: BioPlex
CST9L
Tdark
Novelty: 0.21941207
p_int: 0.988964726
p_ni: 0.010397742
p_wrong: 0.000637531
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.98880754
p_ni: 0.011177122
p_wrong: 0.000015338
Data Source: BioPlex
Publication Statistics
PubMed Score  58.25

PubMed score by year
PubTator Score  55.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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