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Tbio
SLC28A1
Sodium/nucleoside cotransporter 1

Protein Summary
Description
Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286749
  • ENSP00000286749
  • ENSG00000156222
  • ENST00000338602
  • ENSP00000341629
  • ENST00000394573
  • ENSP00000378074

Symbol
  • CNT1
  • CNT1
  • HCNT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
microRNA
0.59
cell line
0.56
cell type or tissue
0.55


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.95   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.95   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
8.3
heel bone mineral density
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
8.3
heel bone mineral density
1
1.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 28 member 1
VGNC:7774
453611
Macaque
solute carrier family 28 member 1
100426175
Mouse
MGI:3605073
434203
Rat
RGD:621223
116642
Horse
solute carrier family 28 member 1
VGNC:23135
100053140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 28 member 1
Macaque
solute carrier family 28 member 1
Mouse
Rat
Horse
solute carrier family 28 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00337-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (48)
1 – 10 of 48
SLC29A1
Tclin
Family: Transporter
Novelty: 0.002085
Score: 0.898
Data Source: STRINGDB
SLC29A2
Tbio
Family: Transporter
Novelty: 0.00801619
Score: 0.873
Data Source: STRINGDB
SLC22A1
Tchem
Family: Transporter
Novelty: 0.00427728
Score: 0.756
Data Source: STRINGDB
SLC29A3
Tbio
Family: Transporter
Novelty: 0.01133239
Score: 0.733
Data Source: STRINGDB
CDA
Tchem
Family: Enzyme
Novelty: 0.00280981
Score: 0.683
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.677
Data Source: STRINGDB
SLC22A15
Tdark
Family: Transporter
Novelty: 0.22792289
Score: 0.673
Data Source: STRINGDB
SLC4A8
Tbio
Family: Transporter
Novelty: 0.01606111
Score: 0.641
Data Source: STRINGDB
SLC29A4
Tchem
Family: Transporter
Novelty: 0.00772914
Score: 0.599
Data Source: STRINGDB
SLC22A7
Tbio
Family: Transporter
Novelty: 0.00964024
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score  132.95

PubMed score by year
PubTator Score  84.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer