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Tbio
PDHX
Pyruvate dehydrogenase protein X component, mitochondrial

Protein Summary
Description
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimito ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227868
  • ENSP00000227868
  • ENSG00000110435
  • ENST00000430469
  • ENSP00000415695
  • ENST00000448838
  • ENSP00000389404

Symbol
  • PDX1
  • E3BP
  • OPDX
  • PDX1
  • proX
  • DLDBP
  • PDHXD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.89
protein domain
0.85
histone modification site profile
0.76
virus perturbation
0.76
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.64   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.64   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
93.5
4
3
0
1.2
84.3
1
1
0
1
17.1
sex hormone-binding globulin measurement
1
1
1
5.1
bone density
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
93.5
0
1.2
84.3
0
1
17.1
sex hormone-binding globulin measurement
1
5.1
bone density
1
4.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase complex component X
VGNC:3072
451120
Macaque
pyruvate dehydrogenase complex component X
717932
Mouse
MGI:1351627
27402
Rat
RGD:1566332
311254
Dog
pyruvate dehydrogenase complex component X
VGNC:44375
475942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase complex component X
Macaque
pyruvate dehydrogenase complex component X
Mouse
Rat
Dog
pyruvate dehydrogenase complex component X
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00330-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (107)
1 – 10 of 107
DLD
Tbio
Family: Enzyme
Novelty: 0.00214298
p_int: 0.999998313
p_ni: 0.000001687
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PDK3
Tchem
Family: Kinase
Novelty: 0.05009442
p_int: 0.999744824
p_ni: 0.000255176
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
PDHB
Tbio
Family: Enzyme
Novelty: 0.01018086
p_int: 0.998125424
p_ni: 0.001874576
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FOXD4
Tbio
Family: TF
Novelty: 0.11166611
p_int: 0.99642631
p_ni: 0.00357369
Score: 0.701
Data Source: BioPlex,STRINGDB
MIF
Tchem
Novelty: 0.00056843
p_int: 0.987702793
p_ni: 0.012297207
Data Source: BioPlex
MTIF2
Tbio
Novelty: 0.06681774
p_int: 0.957737218
p_ni: 0.04226278
p_wrong: 3e-9
Score: 0.261
Data Source: BioPlex,STRINGDB
PDK1
Tchem
Family: Kinase
Novelty: 0.0078496
p_int: 0.938870863
p_ni: 0.061129137
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PREPL
Tchem
Family: Enzyme
Novelty: 0.02310586
p_int: 0.758703549
p_ni: 0.24129645
Score: 0.219
Data Source: BioPlex,STRINGDB
PDHA1
Tbio
Family: Enzyme
Novelty: 0.00392231
Score: 0.998
Data Source: Reactome,STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.64

PubMed score by year
PubTator Score  103.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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