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Tclin
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Protein Summary
Description
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell recepto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377346
  • ENSP00000366563
  • ENSG00000171608

Symbol
  • APDS
  • PI3K
  • IMD14
  • p110D
  • P110DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.97
molecular function
0.96
pathway
0.91
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.15   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.15   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1238
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (244)
1 – 10 of 244
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.994
Data Source:  Reactome,STRINGDB
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
Score:  0.987
Data Source:  Reactome,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.977
Data Source:  STRINGDB
PIP5KL1
Tbio
Family:  Enzyme
Novelty:  0.15208771
Score:  0.97
Data Source:  STRINGDB
PIP5K1B
Tbio
Family:  Kinase
Novelty:  0.05013433
Score:  0.969
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.969
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.964
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.964
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.962
Data Source:  STRINGDB
Pathways (240)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Gene Ontology Terms (49)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
83
eosinophil percentage of leukocytes
1
1
1
71.6
1
1
0
1.1
56.6
monocyte count
2
1
2
45.1
lymphocyte count
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
83
eosinophil percentage of leukocytes
1
71.6
0
1.1
56.6
monocyte count
2
45.1
lymphocyte count
1
5.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
VGNC:8092
457922
Macaque
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
710552
Mouse
MGI:1098211
18707
Rat
RGD:1310990
366508
Dog
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
VGNC:44557
489644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Macaque
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Mouse
Rat
Dog
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Publication Statistics
PubMed Score 192.15
PubMed score by year
PubTator Score 4417.18
PubTator score by year
Patents
Patents by year