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Tbio
UPK1A
Uroplakin-1a

Protein Summary
Description
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of supe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222275
  • ENSP00000222275
  • ENSG00000105668
  • ENST00000379013
  • ENSP00000368298
  • ENST00000616789
  • ENSP00000478942
  • ENST00000617999
  • ENSP00000483176

Symbol
  • TSPAN21
  • UP1A
  • UPIA
  • UPKA
  • TSPAN21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.63
cell type or tissue
0.6
cellular component
0.59
disease perturbation
0.43
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.73   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.73   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (99)
1 – 10 of 99
TMEM62
Tdark
Novelty: 1.79070108
p_int: 0.999979759
p_ni: 0.000019809
p_wrong: 4.32e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
SLC44A1
Tbio
Family: Transporter
Novelty: 0.01499456
p_int: 0.999976264
p_ni: 0.000023686
p_wrong: 5.1e-8
Data Source: BioPlex
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.9999095
p_ni: 0.000090239
p_wrong: 2.6e-7
Data Source: BioPlex
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
p_int: 0.999862023
p_ni: 0.000136311
p_wrong: 0.000001666
Data Source: BioPlex
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
p_int: 0.999788027
p_ni: 0.000055802
p_wrong: 0.000156171
Data Source: BioPlex
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
p_int: 0.999777299
p_ni: 0.000199697
p_wrong: 0.000023004
Data Source: BioPlex
FZD8
Tbio
Family: GPCR
Novelty: 0.01613553
p_int: 0.999753992
p_ni: 0.00020702
p_wrong: 0.000038988
Score: 0.181
Data Source: BioPlex,STRINGDB
CIB1
Tbio
Novelty: 0.00364869
p_int: 0.999689132
p_ni: 0.000004958
p_wrong: 0.00030591
Score: 0.177
Data Source: BioPlex,STRINGDB
DPY19L4
Tdark
Family: Enzyme
Novelty: 0.99997412
p_int: 0.999622689
p_ni: 0.00037656
p_wrong: 7.51e-7
Data Source: BioPlex
DPY19L1
Tdark
Family: Enzyme
Novelty: 0.34765717
p_int: 0.999385121
p_ni: 0.000614852
p_wrong: 2.7e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  56.73

PubMed score by year
PubTator Score  23.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer