CDC7
Cell division cycle 7-related protein kinase
Protein Summary
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
- ENST00000234626
- ENSP00000234626
- ENSG00000097046
- ENST00000428239
- ENSP00000393139
- CDC7L1
- Hsk1
- CDC7L1
- HsCDC7
- huCDC7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.94 | ||
transcription factor binding site profile | 0.91 | ||
histone modification site profile | 0.82 | ||
biological process | 0.81 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 257.25 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 282 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 257.25 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 282 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 281
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0