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Tchem
CDC7
Cell division cycle 7-related protein kinase

Protein Summary
Description
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234626
  • ENSP00000234626
  • ENSG00000097046
  • ENST00000428239
  • ENSP00000393139

Symbol
  • CDC7L1
  • Hsk1
  • CDC7L1
  • HsCDC7
  • huCDC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.91
histone modification site profile
0.82
biological process
0.81
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.37   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.37   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 170
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
18.8
eosinophil percentage of leukocytes
1
1
1
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
18.8
eosinophil percentage of leukocytes
1
10.6
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (237)
1 – 10 of 237
DBF4B
Tbio
Novelty: 0.48127081
p_int: 0.999751646
p_ni: 0.000248354
Score: 0.993
Data Source: BioPlex,STRINGDB
DBF4
Tbio
Novelty: 0.00881323
p_int: 0.999448184
p_ni: 0.000551816
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.995176251
p_ni: 0.004823749
Data Source: BioPlex
HHIPL1
Tdark
Novelty: 0.57780473
p_int: 0.760184018
p_ni: 0.239815982
Data Source: BioPlex
MCM4
Tbio
Novelty: 0.00604311
Score: 0.999
Data Source: STRINGDB
MCM10
Tbio
Novelty: 0.0136058
Score: 0.999
Data Source: Reactome,STRINGDB
MCM5
Tbio
Novelty: 0.00716583
Score: 0.999
Data Source: STRINGDB
ORC6
Tbio
Novelty: 0.02529139
Score: 0.999
Data Source: STRINGDB
MCM2
Tbio
Novelty: 0.00276275
Score: 0.999
Data Source: STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  237.37

PubMed score by year
PubTator Score  105.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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