Tbio WWP2 NEDD4-like E3 ubiquitin-protein ligase WWP2

Protein Summary

Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• O00308
• A6NEP1
• B2R706
• B4DTL5
• F5H213
• H3BRF3
• I3RSG8
• Q6ZTQ5
• Q96CZ2
• Q9BWN6

Gene Name

• WWP2

Ensembl ID

• ENST00000356003
• ENSP00000348283
• ENSG00000198373
• ENST00000359154
• ENSP00000352069
• ENST00000568684
• ENSP00000456216
• ENST00000569174
• ENSP00000455311

Symbol

• AIP2
• WWp2-like

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.99
transcription factor	0.9
transcription factor perturbation	0.84
transcription factor binding site profile	0.81

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Nedd4-like E3 Ubiquitin-protein Ligase Wwp2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Nedd4-like E3 Ubiquitin-protein Ligase Wwp2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.64   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.64   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0