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Tbio
WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor supp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356003
  • ENSP00000348283
  • ENSG00000198373
  • ENST00000359154
  • ENSP00000352069
  • ENST00000568684
  • ENSP00000456216
  • ENST00000569174
  • ENSP00000455311

Symbol
  • AIP2
  • WWp2-like
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
transcription factor
0.9
transcription factor perturbation
0.84
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.81   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.81   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
86.5
mathematical ability
2
1
2
69.5
self reported educational attainment
1
1
1
65.2
osteoarthritis, knee
1
1
0
1.1
64.1
vital capacity
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
86.5
mathematical ability
2
69.5
self reported educational attainment
1
65.2
osteoarthritis, knee
0
1.1
64.1
vital capacity
1
59.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW domain containing E3 ubiquitin protein ligase 2
VGNC:5956
743862
Mouse
MGI:1914144
66894
Rat
RGD:1310091
291999
Dog
WW domain containing E3 ubiquitin protein ligase 2
VGNC:48444
479672
Horse
WW domain containing E3 ubiquitin protein ligase 2
VGNC:25061
100067291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW domain containing E3 ubiquitin protein ligase 2
Mouse
Rat
Dog
WW domain containing E3 ubiquitin protein ligase 2
Horse
WW domain containing E3 ubiquitin protein ligase 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00308-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
NOTCH3 Activation and Transmission of Signal to the Nucleus
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Regulation of PTEN stability and activity
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
NOTCH3 Activation and Transmission of Signal to the Nucleus
PIP3 activates AKT signaling
PTEN Regulation
Regulation of PTEN stability and activity
Gene Ontology Terms (31)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (103)
1 – 10 of 103
ARRDC1
Tbio
Novelty: 0.10481621
p_int: 0.999949662
p_ni: 0.000050338
Score: 0.87
Data Source: BioPlex,STRINGDB
AMOTL1
Tbio
Novelty: 0.03842225
p_int: 0.998260433
p_ni: 0.001739553
p_wrong: 1.3e-8
Score: 0.25
Data Source: BioPlex,STRINGDB
TMEM255A
Tdark
Novelty: 1.03700118
p_int: 0.975778515
p_ni: 0.024221485
Score: 0.189
Data Source: BioPlex,STRINGDB
FAM168A
Tbio
Novelty: 0.08308907
p_int: 0.966554096
p_ni: 0.033342387
p_wrong: 0.000103517
Score: 0.302
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.955979982
p_ni: 0.044020018
Score: 0.206
Data Source: BioPlex,STRINGDB
AMOT
Tbio
Novelty: 0.01269856
p_int: 0.923091714
p_ni: 0.076908286
Score: 0.253
Data Source: BioPlex,STRINGDB
FBXO11
Tbio
Novelty: 0.02762674
p_int: 0.866381681
p_ni: 0.133618319
Score: 0.153
Data Source: BioPlex,STRINGDB
CPSF6
Tbio
Novelty: 0.01263178
p_int: 0.839679222
p_ni: 0.160320778
Score: 0.225
Data Source: BioPlex,STRINGDB
TMEM51
Tdark
Novelty: 0.54147214
p_int: 0.826446471
p_ni: 0.173553529
Score: 0.183
Data Source: BioPlex,STRINGDB
POLR2A
Tbio
Family: Enzyme
Novelty: 0.00188323
p_int: 0.778580816
p_ni: 0.221419184
Score: 0.536
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  57.81

PubMed score by year
PubTator Score  37.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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