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Tbio
CACNB4
Voltage-dependent L-type calcium channel subunit beta-4

Protein Summary
Description
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201943
  • ENSP00000201943
  • ENSG00000182389
  • ENST00000534999
  • ENSP00000443893
  • ENST00000539935
  • ENSP00000438949
  • ENST00000638005
  • ENSP00000489677

Symbol
  • CACNLB4
  • EA5
  • EJM
  • CAB4
  • EIG9
  • EJM4
  • EJM6
  • CACNLB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.88
kinase perturbation
0.81
histone modification site profile
0.79
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.74   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.74   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
63.6
idiopathic dilated cardiomyopathy
1
1
0
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
63.6
idiopathic dilated cardiomyopathy
0
1
16.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
calcium voltage-gated channel auxiliary subunit beta 4
695172
Mouse
MGI:103301
12298
Rat
RGD:68385
58942
Dog
calcium voltage-gated channel auxiliary subunit beta 4
VGNC:54803
609361
Horse
calcium voltage-gated channel auxiliary subunit beta 4
VGNC:51443
100057916
Species
Name
OMA
EggNOG
Inparanoid
Macaque
calcium voltage-gated channel auxiliary subunit beta 4
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit beta 4
Horse
calcium voltage-gated channel auxiliary subunit beta 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00305-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Muscle contraction
Reactome
NCAM signaling for neurite out-growth
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Muscle contraction
NCAM signaling for neurite out-growth
Protein-Protein Interactions (125)
1 – 10 of 125
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
p_int: 0.999996984
p_ni: 0.000003016
Score: 0.94
Data Source: BioPlex,STRINGDB
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.854964085
p_ni: 0.145035915
Score: 0.187
Data Source: BioPlex,STRINGDB
CACNA1A
Tchem
Family: IC
Novelty: 0.00069217
Score: 0.991
Data Source: Reactome,STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.983
Data Source: Reactome,STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.981
Data Source: Reactome,STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.976
Data Source: Reactome,STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.11899252
Score: 0.975
Data Source: STRINGDB
CACNA1S
Tclin
Family: IC
Novelty: 0.00434282
Score: 0.971
Data Source: Reactome,STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.971
Data Source: Reactome,STRINGDB
CACNA2D3
Tbio
Family: IC
Novelty: 0.05267262
Score: 0.971
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  59.74

PubMed score by year
PubTator Score  16.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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