Tbio CACNB4 Voltage-dependent L-type calcium channel subunit beta-4

Protein Summary

Description

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• O00305
• A7BJ74
• A8K1Y4
• B4DG40
• O60515
• Q6B000
• Q96L40
• CAB4

Gene Name

• CACNB4

Ensembl ID

• ENST00000201943
• ENSP00000201943
• ENSG00000182389
• ENST00000534999
• ENSP00000443893
• ENST00000539935
• ENSP00000438949
• ENST00000638005
• ENSP00000489677

Symbol

• CACNLB4
• EA5
• EJM
• CAB4
• EIG9
• EJM4
• EJM6
• CACNLB4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
molecular function	0.88
kinase perturbation	0.81
histone modification site profile	0.79
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Voltage-dependent L-type Calcium Channel Subunit Beta-4

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Voltage-dependent L-type Calcium Channel Subunit Beta-4

DTO Classes

Protein / Ion Channel / Calcium Channel Auxiliary Subunit Types 1-4 (Cca-) Family / Voltage-dependent L-type Calcium Channel Subunit Beta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.31   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.31   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0