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Tbio
EIF3F
Eukaryotic translation initiation factor 3 subunit F

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309828
  • ENSP00000310040
  • ENSG00000175390
  • ENST00000533626
  • ENSP00000431800
  • ENST00000626223
  • ENSP00000485772
  • ENSG00000280606
  • ENST00000628056
  • ENSP00000486798

Symbol
  • EIF3S5
  • MRT67
  • EIF3S5
  • eIF3-p47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
virus perturbation
0.83
hub protein
0.82
transcription factor perturbation
0.8
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
41.9
mean corpuscular volume
1
1
1
40.3
mean corpuscular hemoglobin concentration
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
41.9
mean corpuscular volume
1
40.3
mean corpuscular hemoglobin concentration
1
8.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit F
VGNC:6485
451007
Macaque
eukaryotic translation initiation factor 3 subunit F
706269
Mouse
MGI:1913335
66085
Rat
RGD:1306112
293427
Dog
eukaryotic translation initiation factor 3 subunit F
VGNC:40272
476840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit F
Macaque
eukaryotic translation initiation factor 3 subunit F
Mouse
Rat
Dog
eukaryotic translation initiation factor 3 subunit F
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00303-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Protein-Protein Interactions (279)
1 – 10 of 279
EIF3M
Tbio
Novelty: 0.0174915
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3H
Tbio
Novelty: 0.02564681
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3CL
Tdark
Novelty: 0.15875888
p_int: 0.999999957
p_ni: 4.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3E
Tbio
Novelty: 0.02154456
p_int: 0.999999911
p_ni: 8.9e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3I
Tbio
Novelty: 0.04398155
p_int: 0.999998358
p_ni: 0.000001642
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3L
Tbio
Novelty: 0.11054104
p_int: 0.999992793
p_ni: 0.000007207
Score: 0.999
Data Source: BioPlex,STRINGDB
LRRC49
Tdark
Novelty: 0.19477281
p_int: 0.999968078
p_ni: 0.000031922
Score: 0.732
Data Source: BioPlex,STRINGDB
EIF3G
Tbio
Novelty: 0.04737601
p_int: 0.999956779
p_ni: 0.000043221
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3A
Tbio
Novelty: 0.00434615
p_int: 0.999936373
p_ni: 0.000063627
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3C
Tbio
Novelty: 0.02844331
p_int: 0.999836791
p_ni: 0.000163209
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.18

PubMed score by year
PubTator Score  21.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer