Tbio TNFRSF11B Tumor necrosis factor receptor superfamily member 11B

Protein Summary

Description

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00300
• B2R9A8
• O60236
• Q53FX6
• Q9UHP4

Gene Name

• TNFRSF11B

Ensembl ID

• ENST00000297350
• ENSP00000297350
• ENSG00000164761

Symbol

• OCIF
• OPG
• OPG
• TR1
• OCIF
• PDB5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
gene perturbation	0.98
disease	0.85
kinase perturbation	0.84
cell type or tissue	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.8   (req: < 5)

Gene RIFs: 738   (req: <= 3)

Antibodies: 715   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.8   (req: >= 5)

Gene RIFs: 738   (req: > 3)

Antibodies: 715   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0