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Tbio
TNFRSF11B
Tumor necrosis factor receptor superfamily member 11B

Protein Summary
Description
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297350
  • ENSP00000297350
  • ENSG00000164761

Symbol
  • OCIF
  • OPG
  • OPG
  • TR1
  • OCIF
  • PDB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
gene perturbation
0.98
disease
0.85
kinase perturbation
0.84
cell type or tissue
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.08   (req: < 5)
Gene RIFs: 608   (req: <= 3)
Antibodies: 715   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.08   (req: >= 5)
Gene RIFs: 608   (req: > 3)
Antibodies: 715   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
12
9
14
97.2
heel bone mineral density
3
6
9
96.7
alkaline phosphatase measurement
3
2
2
19.5
95.5
spine bone mineral density
1
1
1
77
osteoprotegerin measurement
1
2
2
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
14
97.2
heel bone mineral density
9
96.7
alkaline phosphatase measurement
2
19.5
95.5
spine bone mineral density
1
77
osteoprotegerin measurement
2
76.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 11b
VGNC:2999
464351
Macaque
TNF receptor superfamily member 11b
701850
Mouse
MGI:109587
18383
Rat
RGD:619802
25341
Dog
TNF receptor superfamily member 11b
VGNC:47655
100855848
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 11b
Macaque
TNF receptor superfamily member 11b
Mouse
Rat
Dog
TNF receptor superfamily member 11b
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00300-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (118)
1 – 10 of 118
TNFSF11
Tclin
Novelty:  0.00018328
Score:  0.999
Data Source:  Reactome,STRINGDB
TNFSF10
Tchem
Novelty:  0.00096612
Score:  0.968
Data Source:  STRINGDB
BGLAP
Tbio
Novelty:  0.00009678
Score:  0.892
Data Source:  STRINGDB
ACP5
Tbio
Family:  Enzyme
Novelty:  0.00034703
Score:  0.86
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.813
Data Source:  STRINGDB
RUNX2
Tbio
Family:  TF
Novelty:  0.00028804
Score:  0.8
Data Source:  STRINGDB
SOST
Tclin
Novelty:  0.0009273
Score:  0.792
Data Source:  STRINGDB
CTSK
Tchem
Family:  Enzyme
Novelty:  0.0007707
Score:  0.774
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.762
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.736
Data Source:  STRINGDB
Publication Statistics
PubMed Score  158.08

PubMed score by year
PubTator Score  2288.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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