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Tbio
CLIC1
Chloride intracellular channel protein 1

Protein Summary
Description
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375779
  • ENSP00000364934
  • ENSG00000213719
  • ENST00000375780
  • ENSP00000364935
  • ENST00000375784
  • ENSP00000364940
  • ENST00000383404
  • ENSP00000372896
  • ENSG00000206394
  • ENST00000383405
  • ENSP00000372897
  • ENST00000395892
  • ENSP00000379229
  • ENST00000400052
  • ENSP00000382926
  • ENST00000400058
  • ENSP00000382931
  • ENST00000415179
  • ENSP00000409247
  • ENSG00000226248
  • ENST00000418285
  • ENSP00000407791
  • ENSG00000226417
  • ENST00000420458
  • ENSP00000410965
  • ENSG00000226651
  • ENST00000422167
  • ENSP00000407429
  • ENST00000423055
  • ENSP00000406968
  • ENST00000423143
  • ENSP00000404589
  • ENSG00000223639
  • ENST00000423804
  • ENSP00000409979
  • ENSG00000230685
  • ENST00000425464
  • ENSP00000401292
  • ENST00000431921
  • ENSP00000408357
  • ENST00000433916
  • ENSP00000391395
  • ENST00000434202
  • ENSP00000400532
  • ENST00000435242
  • ENSP00000412217
  • ENST00000438708
  • ENSP00000406088
  • ENST00000438750
  • ENSP00000404037
  • ENST00000442045
  • ENSP00000400280
  • ENST00000447338
  • ENSP00000413330
  • ENST00000447369
  • ENSP00000408094
  • ENST00000451546
  • ENSP00000416211
  • ENST00000456863
  • ENSP00000406335
  • ENST00000457485
  • ENSP00000398056
  • ENST00000614673
  • ENSP00000480256
  • ENST00000614982
  • ENSP00000477623
  • ENST00000616760
  • ENSP00000479808
  • ENST00000618288
  • ENSP00000479501
  • ENST00000619727
  • ENSP00000482255
  • ENST00000621055
  • ENSP00000478930
  • ENST00000622613
  • ENSP00000484581

Symbol
  • G6
  • NCC27
  • G6
  • CL1C1
  • NCC27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
PubMedID
0.91
virus perturbation
0.88
disease perturbation
0.87
co-expressed gene
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.42   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.42   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (385)
Items per page:
1 – 5 of 385
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
Items per page:
1 – 5 of 385
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 1
VGNC:52009
462564
Macaque
chloride intracellular channel 1
715446
Mouse
MGI:2148924
114584
Rat
RGD:1303043
406864
Dog
chloride intracellular channel 1
474847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 1
Macaque
chloride intracellular channel 1
Mouse
Rat
Dog
chloride intracellular channel 1
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00299-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (24)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (181)
1 – 10 of 181
TPRN
Tbio
Novelty:  0.05784581
p_int:  0.999999581
p_ni:  4.19e-7
Score:  0.321
Data Source:  BioPlex,STRINGDB
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.999981577
p_ni:  0.000018423
Score:  0.206
Data Source:  BioPlex,STRINGDB
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.946825428
p_ni:  0.053174572
Score:  0.267
Data Source:  BioPlex,STRINGDB
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
Score:  0.92
Data Source:  STRINGDB
G6PC
Tchem
Family:  Enzyme
Novelty:  0.00088094
Score:  0.885
Data Source:  STRINGDB
BAG6
Tbio
Novelty:  0.0035578
Score:  0.837
Data Source:  STRINGDB
G6PD
Tchem
Family:  Enzyme
Novelty:  0.00064455
Score:  0.807
Data Source:  STRINGDB
SLC37A4
Tchem
Family:  Transporter
Novelty:  0.00787533
Score:  0.8
Data Source:  STRINGDB
H6PD
Tbio
Novelty:  0.00366637
Score:  0.793
Data Source:  STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
Score:  0.792
Data Source:  STRINGDB
Publication Statistics
PubMed Score  184.42

PubMed score by year
PubTator Score  140.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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