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Tbio
TULP1
Tubby-related protein 1

Protein Summary
Description
Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. The protein encoded by this gene is thought to play a role in the physiolo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229771
  • ENSP00000229771
  • ENSG00000112041
  • ENST00000322263
  • ENSP00000319414

Symbol
  • TUBL1
  • RP14
  • LCA15
  • TUBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
molecular function
0.81
cellular component
0.67
gene perturbation
0.67
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.35   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.35   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
Score:  0.832
Data Source:  STRINGDB
CRB1
Tbio
Novelty:  0.00560299
Score:  0.821
Data Source:  STRINGDB
AIPL1
Tbio
Novelty:  0.01436649
Score:  0.813
Data Source:  STRINGDB
SPATA7
Tbio
Novelty:  0.07689485
Score:  0.811
Data Source:  STRINGDB
LCA5
Tbio
Novelty:  0.0379066
Score:  0.792
Data Source:  STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.75
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.74
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.732
Data Source:  STRINGDB
RD3
Tbio
Novelty:  0.00651981
Score:  0.718
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
11
95.7
heel bone mineral density
3
4
6
85.3
birth weight
2
2
2
68.2
eosinophil percentage of leukocytes
1
2
2
67.6
eosinophil count
2
3
3
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
95.7
heel bone mineral density
6
85.3
birth weight
2
68.2
eosinophil percentage of leukocytes
2
67.6
eosinophil count
3
65.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 1
VGNC:3778
462638
Macaque
tubby like protein 1
718796
Mouse
MGI:109571
22157
Rat
RGD:1311062
309900
Dog
tubby like protein 1 [Source:HGNC Symbol;Acc:HGNC:12423]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 1
Macaque
tubby like protein 1
Mouse
Rat
Dog
tubby like protein 1 [Source:HGNC Symbol;Acc:HGNC:12423]
Publication Statistics
PubMed Score 60.35
PubMed score by year
PubTator Score 37.31
PubTator score by year
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Related Publications
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PMID
Year
Title