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Tbio
LEFTY2
Left-right determination factor 2

Protein Summary
Description
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366820
  • ENSP00000355785
  • ENSG00000143768
  • ENST00000420304
  • ENSP00000388009

Symbol
  • EBAF
  • LEFTA
  • LEFTYA
  • TGFB4
  • EBAF
  • LEFTA
  • TGFB4
  • LEFTYA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.85
PubMedID
0.84
cell type or tissue
0.76
biological process
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.06   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.06   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (141)
1 – 10 of 141
LEFTY1
Tbio
Novelty:  0.01608284
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.972
Data Source:  BioPlex,STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
Score:  0.982
Data Source:  Reactome,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.981
Data Source:  Reactome,STRINGDB
CFC1
Tbio
Novelty:  0.01787772
Score:  0.974
Data Source:  Reactome,STRINGDB
NODAL
Tbio
Novelty:  0.01033642
Score:  0.973
Data Source:  Reactome,STRINGDB
ACVR1B
Tchem
Family:  Kinase
Novelty:  0.00633595
Score:  0.966
Data Source:  Reactome,STRINGDB
ACVR1C
Tbio
Family:  Kinase
Novelty:  0.01675672
Score:  0.954
Data Source:  Reactome,STRINGDB
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
Score:  0.947
Data Source:  Reactome,STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.928
Data Source:  STRINGDB
TGFB3
Tbio
Novelty:  0.00068568
Score:  0.923
Data Source:  STRINGDB
Pathways (15)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Regulation of signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Regulation of signaling by NODAL
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
56.4
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
left-right determination factor 2
VGNC:8063
457780
Mouse
MGI:107405
13590
Rat
RGD:1561867
498299
Dog
left-right determination factor 1
490387
Horse
left-right determination factor 1-like
100054366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
left-right determination factor 2
Mouse
Rat
Dog
left-right determination factor 1
Horse
left-right determination factor 1-like
Publication Statistics
PubMed Score 89.06
PubMed score by year
PubTator Score 35.08
PubTator score by year