Pharos : Target Details

Tbio

Protein Summary

Description

Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). The product of this gene is a membrane-associated protein that f ...more

Uniprot Accession IDs

Gene Name

HIP1

Ensembl ID

ENST00000336926
ENSP00000336747
ENSG00000127946
ENST00000434438
ENSP00000410300
ENST00000616821
ENSP00000484528

Symbol

SHON
HIP-I
ILWEQ
SHONbeta
SHONgamma

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96

biological process	0.84

PubMedID	0.83

histone modification site profile	0.79

microRNA	0.78

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53 (req: < 5)

View Publications

Gene RIFs: 31 (req: <= 3)

View Gene RIFs

Antibodies: 242 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53 (req: >= 5)

Gene RIFs: 31 (req: > 3)

Antibodies: 242 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (176)

1 – 10 of 176

See Interactions on String-DB

CPNE2

Tdark

Novelty: 0.24188419

p_int: 0.999999979

p_ni: 1.6e-8

p_wrong: 5e-9

Data Source: BioPlex

DEUP1

Tbio

Novelty: 0.13274391

p_int: 0.999999148

p_ni: 8.52e-7

Score: 0.237

Data Source: BioPlex,STRINGDB

HIP1R

Tbio

Novelty: 0.02502713

p_int: 0.999995028

p_ni: 0.000004827

p_wrong: 1.45e-7

Score: 0.937

Data Source: BioPlex,STRINGDB

CLTC

Tbio

Novelty: 0.00256674

Score: 0.979

Data Source: STRINGDB

CLTB

Tbio

Novelty: 0.00931222

Score: 0.977

Data Source: STRINGDB

EPN1

Tbio

Novelty: 0.01788784

Score: 0.974

Data Source: STRINGDB

CLTA

Tbio

Novelty: 0.01900315

Score: 0.974

Data Source: STRINGDB

CLTCL1

Tbio

Novelty: 0.05667807

Score: 0.972

Data Source: STRINGDB

CTTN

Tbio

Novelty: 0.0017962

Score: 0.971

Data Source: STRINGDB

GAK

Tchem

Family: Kinase

Novelty: 0.00731928

Score: 0.969

Data Source: STRINGDB

Pathways (7)

Reactome (3)

KEGG (1)

PathwayCommons (3)

Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Reactome	Membrane Trafficking	612 targets	R-HSA-199991

Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Membrane Trafficking	612 targets	R-HSA-199991

Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (46)

Functions (14)

Components (16)

Processes (16)

Items per page:

1 – 10 of 14

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL

clathrin binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL

phosphatidylinositol binding	Inferred from Direct Assay (IDA)	UniProtKB

phosphatidylinositol-3,4-bisphosphate binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL

phosphatidylinositol-3,5-bisphosphate binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL

phosphatidylinositol-3-phosphate binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL

protein homodimerization activity	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL

AP-2 adaptor complex binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL

clathrin light chain binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL

protein heterodimerization activity	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL

GWAS Traits (21)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
eosinophil count	EFO_0004842	3	4	5	97.6

eosinophil percentage of leukocytes	EFO_0007991	2	5	5	97.3

basophil count	EFO_0005090	3	3	4	91.5

sum of eosinophil and basophil counts	EFO_0009389	1	2	2	90.8

eosinophil percentage of granulocytes	EFO_0007996	1	2	2	90.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
eosinophil count	EFO_0004842	5	97.6

eosinophil percentage of leukocytes	EFO_0007991	5	97.3

basophil count	EFO_0005090	4	91.5

sum of eosinophil and basophil counts	EFO_0009389	2	90.8

eosinophil percentage of granulocytes	EFO_0007996	2	90.6

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
3D-structure

Actin-binding

Activator

Alternative splicing

Apoptosis

Chromosomal rearrangement

Coiled coil

Complete proteome

Cytoplasm

Cytoplasmic vesicle

GWAS Trait

No Header	No Header
age at first sexual intercourse measurement

basophil count

basophil percentage of granulocytes

basophil percentage of leukocytes

body mass index

C-reactive protein measurement

cognitive function measurement

eosinophil count

eosinophil percentage of granulocytes

eosinophil percentage of leukocytes

MGI Phenotype

No Header	No Header
behavior/neurological phenotype

cellular phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

liver/biliary system phenotype

mortality/aging

muscle phenotype

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID
Macaque	huntingtin interacting protein 1		716133

Mouse	huntingtin interacting protein 1	MGI:1099804	215114

Rat	huntingtin interacting protein 1	RGD:620305	192154

Dog	huntingtin interacting protein 1	VGNC:41691	489814

Horse	huntingtin interacting protein 1	VGNC:18789	100061280

Species	Name	OMA	EggNOG	Inparanoid
Macaque	huntingtin interacting protein 1

Mouse	huntingtin interacting protein 1

Rat	huntingtin interacting protein 1

Dog	huntingtin interacting protein 1

Horse	huntingtin interacting protein 1

Publication Statistics

PubMed Score 25.53

PubMed score by year

PubTator Score 103.84

PubTator score by year