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Tbio
HIP1
Huntingtin-interacting protein 1

Protein Summary
Description
Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). The product of this gene is a membrane-associated protein that f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336926
  • ENSP00000336747
  • ENSG00000127946
  • ENST00000434438
  • ENSP00000410300
  • ENST00000616821
  • ENSP00000484528

Symbol
  • SHON
  • HIP-I
  • ILWEQ
  • SHONbeta
  • SHONgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
biological process
0.84
PubMedID
0.83
histone modification site profile
0.79
microRNA
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
96.7
self reported educational attainment
1
1
1
89.9
basophil count
3
2
3
87.3
body mass index
5
1
6
84.9
2
2
0
1.8
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
96.7
self reported educational attainment
1
89.9
basophil count
3
87.3
body mass index
6
84.9
0
1.8
80
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
huntingtin interacting protein 1
716133
Mouse
MGI:1099804
215114
Rat
RGD:620305
192154
Dog
huntingtin interacting protein 1
VGNC:41691
489814
Horse
huntingtin interacting protein 1
VGNC:18789
100061280
Species
Name
OMA
EggNOG
Inparanoid
Macaque
huntingtin interacting protein 1
Mouse
Rat
Dog
huntingtin interacting protein 1
Horse
huntingtin interacting protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00291-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (176)
1 – 10 of 176
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999999979
p_ni: 1.6e-8
p_wrong: 5e-9
Data Source: BioPlex
DEUP1
Tbio
Novelty: 0.13274391
p_int: 0.999999148
p_ni: 8.52e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.999995028
p_ni: 0.000004827
p_wrong: 1.45e-7
Score: 0.937
Data Source: BioPlex,STRINGDB
CLTC
Tbio
Novelty: 0.00256674
Score: 0.979
Data Source: STRINGDB
CLTB
Tbio
Novelty: 0.00931222
Score: 0.977
Data Source: STRINGDB
EPN1
Tbio
Novelty: 0.01788784
Score: 0.974
Data Source: STRINGDB
CLTA
Tbio
Novelty: 0.01900315
Score: 0.974
Data Source: STRINGDB
CLTCL1
Tbio
Novelty: 0.05667807
Score: 0.972
Data Source: STRINGDB
CTTN
Tbio
Novelty: 0.0017962
Score: 0.971
Data Source: STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.53

PubMed score by year
PubTator Score  103.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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