Tbio HIP1 Huntingtin-interacting protein 1

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Huntingtin-interacting Protein 1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Huntingtin-interacting Protein 1

Protein Summary

Description

Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O00291
• B4E3I7
• E7ES17
• O00328
• Q2TB58
• Q8TDL4
• V5LU97
• HIP-1

Gene Name

• HIP1

Ensembl ID

• ENST00000336926
• ENSP00000336747
• ENSG00000127946
• ENST00000434438
• ENSP00000410300
• ENST00000616821
• ENSP00000484528

Symbol

• SHON
• HIP-I
• ILWEQ
• SHONbeta
• SHONgamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
biological process	0.84
PubMedID	0.83
histone modification site profile	0.79
microRNA	0.78

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3	2	3		96.7
self reported educational attainment	EFO_0004784	1	1	1		89.9
basophil count	EFO_0005090	3	2	3		87.3
body mass index	EFO_0004340	5	1	6		84.9
systemic lupus erythematosus	EFO_0002690	2	2	0	1.8	80

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3		96.7
self reported educational attainment	EFO_0004784	1		89.9
basophil count	EFO_0005090	3		87.3
body mass index	EFO_0004340	6		84.9
systemic lupus erythematosus	EFO_0002690	0	1.8	80

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	huntingtin interacting protein 1		716133
Mouse	huntingtin interacting protein 1	MGI:1099804	215114
Rat	huntingtin interacting protein 1	RGD:620305	192154
Dog	huntingtin interacting protein 1	VGNC:41691	489814
Horse	huntingtin interacting protein 1	VGNC:18789	100061280

Species	Name	OMA	EggNOG	Inparanoid
Macaque	huntingtin interacting protein 1
Mouse	huntingtin interacting protein 1
Rat	huntingtin interacting protein 1
Dog	huntingtin interacting protein 1
Horse	huntingtin interacting protein 1

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00291-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (7)

Reactome (3)

KEGG (1)

PathwayCommons (3)

Clathrin-mediated endocytosis (R-HSA-8856828)

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Find Similar Targets

Items per page:

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (46)

Functions (14)

Components (16)

Processes (16)

Find Similar Targets

Items per page:

10

1 – 10 of 14

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
clathrin binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
phosphatidylinositol binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-3,4-bisphosphate binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
phosphatidylinositol-3,5-bisphosphate binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
phosphatidylinositol-3-phosphate binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
protein homodimerization activity	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
AP-2 adaptor complex binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
clathrin light chain binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL

Protein-Protein Interactions (176)

Explore Interacting Targets

1 – 10 of 176

• See Interactions on String-DB

CPNE2

Tdark

Novelty: 0.24188419

p_int: 0.999999979

p_ni: 1.6e-8

p_wrong: 5e-9

Data Source: BioPlex

DEUP1

Tbio

Novelty: 0.13274391

p_int: 0.999999148

p_ni: 8.52e-7

Score: 0.237

Data Source: BioPlex,STRINGDB

HIP1R

Tbio

Novelty: 0.02502713

p_int: 0.999995028

p_ni: 0.000004827

p_wrong: 1.45e-7

Score: 0.937

Data Source: BioPlex,STRINGDB

CLTC

Tbio

Novelty: 0.00256674

Score: 0.979

Data Source: STRINGDB

CLTB

Tbio

Novelty: 0.00931222

Score: 0.977

Data Source: STRINGDB

EPN1

Tbio

Novelty: 0.01788784

Score: 0.974

Data Source: STRINGDB

CLTA

Tbio

Novelty: 0.01900315

Score: 0.974

Data Source: STRINGDB

CLTCL1

Tbio

Novelty: 0.05667807

Score: 0.972

Data Source: STRINGDB

CTTN

Tbio

Novelty: 0.0017962

Score: 0.971

Data Source: STRINGDB

GAK

Tchem

Family: Kinase

Novelty: 0.00731928

Score: 0.969

Data Source: STRINGDB

Publication Statistics

PubMed Score  25.53

PubMed score by year

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PubTator Score  103.84

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Actin-binding
Activator
Alternative splicing
Apoptosis
Chromosomal rearrangement
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle

GWAS Trait Find Similar Targets

basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes
body mass index
mathematical ability
physical activity measurement
self reported educational attainment
systemic lupus erythematosus

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
muscle phenotype