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Tbio
RFXAP
Regulatory factor X-associated protein

Protein Summary
Description
Part of the RFX complex that binds to the X-box of MHC II promoters. Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255476
  • ENSP00000255476
  • ENSG00000133111
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.7
tissue sample
0.67
small molecule perturbation
0.65
histone modification site profile
0.62
transcription factor binding site profile
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.15   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.15   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
RFX5
Tbio
Family:  TF
Novelty:  0.02002111
p_int:  0.999999999
Score:  0.998
Data Source:  BioPlex,STRINGDB
RFXANK
Tbio
Novelty:  0.00355465
Score:  0.982
Data Source:  STRINGDB
CIITA
Tbio
Novelty:  0.00245662
Score:  0.948
Data Source:  STRINGDB
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
Score:  0.81
Data Source:  STRINGDB
RFX7
Tdark
Family:  TF
Novelty:  0.15609316
Score:  0.699
Data Source:  STRINGDB
ANKRA2
Tbio
Novelty:  0.19358401
Score:  0.674
Data Source:  STRINGDB
TMEM238
Tdark
Novelty:  2.44897959
Score:  0.669
Data Source:  STRINGDB
RFX2
Tbio
Family:  TF
Novelty:  0.04660141
Score:  0.647
Data Source:  STRINGDB
GPR146
Tbio
Family:  GPCR
Novelty:  0.10269429
Score:  0.618
Data Source:  STRINGDB
TRHDE
Tbio
Family:  Enzyme
Novelty:  0.02084006
Score:  0.614
Data Source:  STRINGDB
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Tuberculosis
KEGG
Primary immunodeficiency
KEGG
Antigen processing and presentation
Name
Explore in Pharos
Explore in Source
Tuberculosis
Primary immunodeficiency
Antigen processing and presentation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
81.5
1
1
0
1.1
46.9
bone density
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
81.5
0
1.1
46.9
bone density
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X associated protein
VGNC:5100
100610983
Macaque
regulatory factor X associated protein
694441
Mouse
MGI:2180854
170767
Rat
RGD:9303218
103691557
Dog
regulatory factor X associated protein [Source:HGNC Symbol;Acc:HGNC:9988]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X associated protein
Macaque
regulatory factor X associated protein
Mouse
Rat
Dog
regulatory factor X associated protein [Source:HGNC Symbol;Acc:HGNC:9988]
Publication Statistics
PubMed Score 21.15
PubMed score by year
PubTator Score 22.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title