Tbio DFFA DNA fragmentation factor subunit alpha

Protein Summary

Description

Inhibitor of the caspase-activated DNase (DFF40). Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00273
• Q5T6G5
• Q5T6G6
• Q96I97
• Q9Y6C6

Gene Name

• DFFA

Ensembl ID

• ENST00000377036
• ENSP00000366235
• ENSG00000160049
• ENST00000377038
• ENSP00000366237

Symbol

• DFF1
• DFF45
• DFF1
• ICAD
• DFF-45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
transcription factor perturbation	0.74
virus perturbation	0.72
tissue	0.71
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.17   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 791   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.17   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 791   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0