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Tbio
DFFA
DNA fragmentation factor subunit alpha

Protein Summary
Description
Inhibitor of the caspase-activated DNase (DFF40). Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377036
  • ENSP00000366235
  • ENSG00000160049
  • ENST00000377038
  • ENSP00000366237

Symbol
  • DFF1
  • DFF45
  • DFF1
  • ICAD
  • DFF-45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
transcription factor perturbation
0.74
virus perturbation
0.72
tissue
0.71
tissue sample
0.69


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.59   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 791   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.59   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 791   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA fragmentation factor subunit alpha
VGNC:7385
457928
Macaque
DNA fragmentation factor subunit alpha
713544
Mouse
MGI:1196227
13347
Rat
RGD:620334
114214
Dog
DNA fragmentation factor subunit alpha
487449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA fragmentation factor subunit alpha
Macaque
DNA fragmentation factor subunit alpha
Mouse
Rat
Dog
DNA fragmentation factor subunit alpha
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (52)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Programmed Cell Death
Protein-Protein Interactions (64)
1 – 10 of 64
DFFB
Tbio
Novelty: 0.00475349
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TSPYL4
Tdark
Novelty: 0.4538252
p_int: 0.999999933
p_ni: 6.7e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.985
Data Source: Reactome,STRINGDB
GZMB
Tchem
Family: Enzyme
Novelty: 0.00052869
Score: 0.915
Data Source: STRINGDB
CIDEB
Tbio
Novelty: 0.01514215
Score: 0.914
Data Source: STRINGDB
KPNB1
Tbio
Novelty: 0.01469696
Score: 0.904
Data Source: Reactome,STRINGDB
KPNA1
Tbio
Novelty: 0.00863582
Score: 0.9
Data Source: Reactome,STRINGDB
CASP7
Tchem
Family: Enzyme
Novelty: 0.00126224
Score: 0.729
Data Source: STRINGDB
CIDEC
Tbio
Novelty: 0.01081754
Score: 0.723
Data Source: STRINGDB
DNASE2
Tbio
Family: Enzyme
Novelty: 0.01869454
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  370.59

PubMed score by year
PubTator Score  150.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer