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Tbio
TAF4
Transcription initiation factor TFIID subunit 4

Protein Summary
Description
Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252996
  • ENSP00000252996
  • ENSG00000130699

Symbol
  • TAF2C
  • TAF2C1
  • TAF4A
  • TAFII130
  • TAFII135
  • TAF2C
  • TAF4A
  • TAF2C1
  • TAFII130
  • TAFII135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
protein complex
0.74
kinase perturbation
0.71
biological process
0.63
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
61.5
testosterone measurement
1
1
1
51.9
body mass index
1
1
1
25.3
mean corpuscular volume
1
1
1
23.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
61.5
testosterone measurement
1
51.9
body mass index
1
25.3
mean corpuscular volume
1
23.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 4
VGNC:6313
458381
Macaque
TATA-box binding protein associated factor 4
720204
Mouse
MGI:2152346
228980
Dog
TATA-box binding protein associated factor 4
VGNC:54737
477280
Horse
TATA-box binding protein associated factor 4
VGNC:51619
100057726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 4
Macaque
TATA-box binding protein associated factor 4
Mouse
Dog
TATA-box binding protein associated factor 4
Horse
TATA-box binding protein associated factor 4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (173)
1 – 10 of 173
TAF8
Tbio
Novelty: 0.01056638
p_int: 0.9999994
p_ni: 6e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999998606
p_ni: 0.000001394
Score: 0.999
Data Source: BioPlex,STRINGDB
SPATA25
Tbio
Novelty: 0.80142563
p_int: 0.999998492
p_ni: 0.000001508
Data Source: BioPlex
TAF7L
Tbio
Novelty: 0.08132691
p_int: 0.999996396
p_ni: 0.000003604
Score: 0.997
Data Source: BioPlex,STRINGDB
TAF11
Tbio
Novelty: 0.10299251
Score: 0.999
Data Source: STRINGDB
TAF7
Tbio
Novelty: 0.05316615
Score: 0.999
Data Source: STRINGDB
TBP
Tbio
Novelty: 0.00034941
Score: 0.999
Data Source: STRINGDB
TAF5
Tbio
Novelty: 0.05443551
Score: 0.999
Data Source: STRINGDB
TAF10
Tbio
Novelty: 0.0276004
Score: 0.999
Data Source: STRINGDB
TAF2
Tbio
Novelty: 0.0397428
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.44

PubMed score by year
PubTator Score  38.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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