Tchem PGRMC1 Membrane-associated progesterone receptor component 1

Protein Summary

Description

Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• O00264
• B7Z1L3
• Q9UGJ9
• mPR

Gene Name

• PGRMC1

Ensembl ID

• ENST00000217971
• ENSP00000217971
• ENSG00000101856
• ENST00000535419
• ENSP00000442821

Symbol

• HPR6.6
• PGRMC
• IZA
• MPR
• Dap1
• HPR6.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.99
disease perturbation	0.9
virus perturbation	0.9
cellular component	0.86

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-associated Progesterone Receptor Component 1

Protein / Receptor / Membrane-associated Progesterone Receptor Component 1

DTO Classes

Protein / Signaling / Membrane-associated Progesterone Receptor Component 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.66   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.66   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1