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Tchem
PGRMC1
Membrane-associated progesterone receptor component 1

Protein Classes
Protein Summary
Description
Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217971
  • ENSP00000217971
  • ENSG00000101856
  • ENST00000535419
  • ENSP00000442821

Symbol
  • HPR6.6
  • PGRMC
  • IZA
  • MPR
  • Dap1
  • HPR6.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
disease perturbation
0.9
virus perturbation
0.9
cellular component
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.62   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.62   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
encorafenib
Rendered image for encorafenib
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
51.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor membrane component 1
VGNC:12538
736142
Macaque
progesterone receptor membrane component 1
711792
Mouse
MGI:1858305
53328
Rat
RGD:70890
291948
Dog
progesterone receptor membrane component 1
VGNC:44470
481029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor membrane component 1
Macaque
progesterone receptor membrane component 1
Mouse
Rat
Dog
progesterone receptor membrane component 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00264-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (179)
1 – 10 of 179
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
p_int:  0.954800635
p_ni:  0.045199365
Score:  0.345
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.842038769
p_ni:  0.157961231
Score:  0.738
Data Source:  BioPlex,STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
p_int:  0.774224731
p_ni:  0.225775269
Score:  0.943
Data Source:  BioPlex,STRINGDB
PLIN3
Tbio
Novelty:  0.00975965
Score:  0.958
Data Source:  STRINGDB
MLEC
Tbio
Novelty:  0.01381941
Score:  0.934
Data Source:  STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
Score:  0.921
Data Source:  STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
Score:  0.916
Data Source:  STRINGDB
SLC2A5
Tbio
Family:  Transporter
Novelty:  0.0032733
Score:  0.909
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.909
Data Source:  STRINGDB
RAP2B
Tbio
Family:  Enzyme
Novelty:  0.00347321
Score:  0.907
Data Source:  STRINGDB
Publication Statistics
PubMed Score  339.62

PubMed score by year
PubTator Score  157.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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