WRB
Tail-anchored protein insertion receptor WRB
Protein Summary
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]
- ENST00000333781
- ENSP00000327716
- ENSG00000182093
- ENST00000380708
- ENSP00000370084
- ENST00000398753
- ENSP00000381737
- ENST00000649170
- ENSP00000496813
- ENST00000650376
- ENSP00000497103
- CHD5
- CHD5
- GET1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
histone modification site profile | 0.76 | ||
disease perturbation | 0.74 | ||
tissue sample | 0.72 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.79 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.79 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0