Tchem MEN1 Menin

Protein Summary

Description

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O00255
• A5HBC6
• A5HBC7
• A5HBC8
• A5HBC9
• A5HBD0
• A5HBD1
• A5HBD2
• O00632
• Q9BUF0
• Q9BUK2

Gene Name

• MEN1

Ensembl ID

• ENST00000312049
• ENSP00000308975
• ENSG00000133895
• ENST00000315422
• ENSP00000323747
• ENST00000337652
• ENSP00000337088
• ENST00000377313
• ENSP00000366530
• ENST00000377321
• ENSP00000366538
• ENST00000377326
• ENSP00000366543
• ENST00000394374
• ENSP00000377899
• ENST00000394376
• ENSP00000377901

Symbol

• SCG2
• MEAI
• SCG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.96
hub protein	0.94
disease perturbation	0.83
phenotype	0.79

Protein Classes

DTO Classes

Calumenin / Sarcalumenin / Meningioma Cell Line / Meningioma Cell / Meningioma / Meningocele / Meningitis

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2095.39   (req: < 5)

Gene RIFs: 256   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2095.39   (req: >= 5)

Gene RIFs: 256   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0