Protein Classes
Protein Summary
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is no ...more
- ENST00000312049
- ENSP00000308975
- ENSG00000133895
- ENST00000315422
- ENSP00000323747
- ENST00000337652
- ENSP00000337088
- ENST00000377313
- ENSP00000366530
- ENST00000377321
- ENSP00000366538
- ENST00000377326
- ENSP00000366543
- ENST00000394374
- ENSP00000377899
- ENST00000394376
- ENSP00000377901
- SCG2
- MEAI
- SCG2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.96 | ||
hub protein | 0.94 | ||
disease perturbation | 0.83 | ||
phenotype | 0.79 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1887.36 (req: < 5)
Gene RIFs: 207 (req: <= 3)
Antibodies: 479 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1887.36 (req: >= 5)
Gene RIFs: 207 (req: > 3)
Antibodies: 479 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 43
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 48
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (48)
1 – 10 of 48
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.4 | 4.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 4.1 | |||||
Protein Data Bank (29)
1 – 5 of 29
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (22)
Reactome (19)
KEGG (2)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 19
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deactivation of the beta-catenin transactivating complex | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deactivation of the beta-catenin transactivating complex | ||||
Formation of the beta-catenin:TCF transactivating complex | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (55)
Functions (8)
Components (12)
Processes (35)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (324)
1 – 10 of 324
CD226
Novelty: 0.00374102
p_int: 0.958818487
p_ni: 0.041181513
Data Source: BioPlex
RBBP5
Novelty: 0.02221059
Score: 0.989
Data Source: STRINGDB
ASH2L
Family: Enzyme
Novelty: 0.01586766
Score: 0.987
Data Source: STRINGDB
WDR5
Novelty: 0.0059945
Score: 0.98
Data Source: STRINGDB
SMAD3
Family: TF
Novelty: 0.00048058
Score: 0.979
Data Source: Reactome,STRINGDB
KMT2D
Family: Epigenetic
Novelty: 0.00380525
Score: 0.976
Data Source: STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.975
Data Source: Reactome,STRINGDB
KMT2A
Family: Epigenetic
Novelty: 0.00192554
Score: 0.969
Data Source: STRINGDB
JUND
Family: TF
Novelty: 0.00277701
Score: 0.957
Data Source: STRINGDB
HDAC1
Family: Epigenetic
Novelty: 0.00065244
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score 1887.36
PubMed score by year
PubTator Score 1599.75
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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