Protein Summary
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is no ...more
- ENST00000312049
- ENSP00000308975
- ENSG00000133895
- ENST00000315422
- ENSP00000323747
- ENST00000337652
- ENSP00000337088
- ENST00000377313
- ENSP00000366530
- ENST00000377321
- ENSP00000366538
- ENST00000377326
- ENSP00000366543
- ENST00000394374
- ENSP00000377899
- ENST00000394376
- ENSP00000377901
- SCG2
- MEAI
- SCG2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.96 | ||
hub protein | 0.94 | ||
disease perturbation | 0.83 | ||
phenotype | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2095.39 (req: < 5)
Gene RIFs: 207 (req: <= 3)
Antibodies: 479 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2095.39 (req: >= 5)
Gene RIFs: 207 (req: > 3)
Antibodies: 479 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 43
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 136
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (136)
Protein-Protein Interactions (324)
Nearest Tclin Targets
Pathways (22)
Reactome (19)
KEGG (2)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deactivation of the beta-catenin transactivating complex | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deactivation of the beta-catenin transactivating complex | ||||
Formation of the beta-catenin:TCF transactivating complex | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (55)
Functions (8)
Components (12)
Processes (35)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 3 | 15 | 15 | 98.9 | |||||
uric acid measurement | 2 | 2 | 1 | 13.8 | 68.6 | ||||
body mass index | 1 | 1 | 1 | 38.2 | |||||
substance abuse | 1 | 1 | 1 | 36.6 | |||||
antisocial behaviour measurement | 1 | 1 | 1 | 36.6 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 15 | 98.9 | |||||
uric acid measurement | 1 | 13.8 | 68.6 | ||||
body mass index | 1 | 38.2 | |||||
substance abuse | 1 | 36.6 | |||||
antisocial behaviour measurement | 1 | 36.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | menin 1 | VGNC:1099 | 743979 | |||||
Macaque | menin 1 | 722041 | ||||||
Mouse | MGI:1316736 | 17283 | ||||||
Rat | RGD:3078 | 29417 | ||||||
Dog | menin 1 | VGNC:43156 | 483758 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | menin 1 | |||||
Macaque | menin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | menin 1 | |||||
Publication Statistics
PubMed Score 2095.39
PubMed score by year
PubTator Score 1599.75
PubTator score by year
Related Publications
Text Mined References (261)
GeneRif Annotations (207)
Items per page:
0 of 0
PMID | Year | Title |
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