Protein Summary
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is no ...more
- ENST00000312049
- ENSP00000308975
- ENSG00000133895
- ENST00000315422
- ENSP00000323747
- ENST00000337652
- ENSP00000337088
- ENST00000377313
- ENSP00000366530
- ENST00000377321
- ENSP00000366538
- ENST00000377326
- ENSP00000366543
- ENST00000394374
- ENSP00000377899
- ENST00000394376
- ENSP00000377901
- SCG2
- MEAI
- SCG2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.96 | ||
hub protein | 0.94 | ||
disease perturbation | 0.83 | ||
phenotype | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2095.39 (req: < 5)
Gene RIFs: 242 (req: <= 3)
Antibodies: 479 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2095.39 (req: >= 5)
Gene RIFs: 242 (req: > 3)
Antibodies: 479 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 43
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 136
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0