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Tchem
MEN1
Menin

Protein Summary
Description
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312049
  • ENSP00000308975
  • ENSG00000133895
  • ENST00000315422
  • ENSP00000323747
  • ENST00000337652
  • ENSP00000337088
  • ENST00000377313
  • ENSP00000366530
  • ENST00000377321
  • ENSP00000366538
  • ENST00000377326
  • ENSP00000366543
  • ENST00000394374
  • ENSP00000377899
  • ENST00000394376
  • ENSP00000377901

Symbol
  • SCG2
  • MEAI
  • SCG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
hub protein
0.94
disease perturbation
0.83
phenotype
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1933.11   (req: < 5)
Gene RIFs: 207   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1933.11   (req: >= 5)
Gene RIFs: 207   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
15
15
99.2
uric acid measurement
2
2
1
13.8
65.3
mean reticulocyte volume
1
1
1
33.1
body mass index
1
1
1
33.1
mathematical ability
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
15
99.2
uric acid measurement
1
13.8
65.3
mean reticulocyte volume
1
33.1
body mass index
1
33.1
mathematical ability
1
28.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
menin 1
VGNC:1099
743979
Macaque
menin 1
722041
Mouse
MGI:1316736
17283
Rat
RGD:3078
29417
Dog
menin 1
VGNC:43156
483758
Species
Name
OMA
EggNOG
Inparanoid
Chimp
menin 1
Macaque
menin 1
Mouse
Rat
Dog
menin 1
Protein Structure (29 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00255-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 29
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Gene Ontology Terms (55)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (324)
1 – 10 of 324
CD226
Tbio
Novelty:  0.00374102
p_int:  0.958818487
p_ni:  0.041181513
Data Source:  BioPlex
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.989
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.987
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.98
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.979
Data Source:  Reactome,STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.976
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.975
Data Source:  Reactome,STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.969
Data Source:  STRINGDB
JUND
Tbio
Family:  TF
Novelty:  0.00277701
Score:  0.957
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1933.11

PubMed score by year
PubTator Score  1599.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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