Tchem MEN1 Menin

Protein Classes

DTO Classes

Calumenin / Sarcalumenin / Meningioma Cell Line / Meningioma Cell / Meningioma / Meningocele / Meningitis

Protein Summary

Description

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O00255
• A5HBC6
• A5HBC7
• A5HBC8
• A5HBC9
• A5HBD0
• A5HBD1
• A5HBD2
• O00632
• Q9BUF0
• Q9BUK2

Gene Name

• MEN1

Ensembl ID

• ENST00000312049
• ENSP00000308975
• ENSG00000133895
• ENST00000315422
• ENSP00000323747
• ENST00000337652
• ENSP00000337088
• ENST00000377313
• ENSP00000366530
• ENST00000377321
• ENSP00000366538
• ENST00000377326
• ENSP00000366543
• ENST00000394374
• ENSP00000377899
• ENST00000394376
• ENSP00000377901

Symbol

• SCG2
• MEAI
• SCG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.96
hub protein	0.94
disease perturbation	0.83
phenotype	0.79

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1933.11   (req: < 5)

Gene RIFs: 207   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1933.11   (req: >= 5)

Gene RIFs: 207   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (136)

Explore Active Ligands

1 – 10 of 136

CHEMBL4211366

MEN1Tchem

IC50 : 9

CHEMBL4530300

MEN1Tchem

IC50 : 9

CHEMBL4585198

MEN1Tchem

Ki : 9

CHEMBL2314822

MEN1Tchem

Kd : 8.85

CHEMBL4551865

MEN1Tchem

Ki : 8.85

CHEMBL4592636

MEN1Tchem

Ki : 8.85

CHEMBL4457657

MEN1Tchem

IC50 : 8.77

CHEMBL4449199

MEN1Tchem

Ki : 8.77

CHEMBL4454017

MEN1Tchem

IC50 : 8.7

CHEMBL4528467

MEN1Tchem

IC50 : 8.7

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	3	15	15		99.2
uric acid measurement	EFO_0004761	2	2	1	13.8	65.3
mean reticulocyte volume	EFO_0010701	1	1	1		33.1
body mass index	EFO_0004340	1	1	1		33.1
mathematical ability	EFO_0004875	1	1	1		28.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	15		99.2
uric acid measurement	EFO_0004761	1	13.8	65.3
mean reticulocyte volume	EFO_0010701	1		33.1
body mass index	EFO_0004340	1		33.1
mathematical ability	EFO_0004875	1		28.1

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	menin 1	VGNC:1099	743979
Macaque	menin 1		722041
Mouse	multiple endocrine neoplasia 1	MGI:1316736	17283
Rat	menin 1	RGD:3078	29417
Dog	menin 1	VGNC:43156	483758

Species	Name	OMA	EggNOG	Inparanoid
Chimp	menin 1
Macaque	menin 1
Mouse	multiple endocrine neoplasia 1
Rat	menin 1
Dog	menin 1

Protein Structure (29 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-O00255-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 29

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (22)

Reactome (19)

KEGG (2)

PathwayCommons (1)

Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Deactivation of the beta-catenin transactivating complex	42 targets	R-HSA-3769402
Reactome	Formation of the beta-catenin:TCF transactivating complex	61 targets	R-HSA-201722
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Deactivation of the beta-catenin transactivating complex	42 targets	R-HSA-3769402
Formation of the beta-catenin:TCF transactivating complex	61 targets	R-HSA-201722
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (55)

Functions (8)

Components (12)

Processes (35)

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10

1 – 8 of 8

GO Term	Evidence	Assigned by
double-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
four-way junction DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein binding, bridging	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
Y-form DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
R-SMAD binding	Inferred from Physical Interaction (IPI)	BHF-UCL
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (324)

Explore Interacting Targets

1 – 10 of 324

• See Interactions on String-DB

CD226

Tbio

Novelty:  0.00374102

p_int:  0.958818487

p_ni:  0.041181513

Data Source:  BioPlex

RBBP5

Tbio

Novelty:  0.02221059

Score:  0.989

Data Source:  STRINGDB

ASH2L

Tbio

Family:  Enzyme

Novelty:  0.01586766

Score:  0.987

Data Source:  STRINGDB

WDR5

Tchem

Novelty:  0.0059945

Score:  0.98

Data Source:  STRINGDB

SMAD3

Tchem

Family:  TF

Novelty:  0.00048058

Score:  0.979

Data Source:  Reactome,STRINGDB

KMT2D

Tbio

Family:  Epigenetic

Novelty:  0.00380525

Score:  0.976

Data Source:  STRINGDB

CTNNB1

Tchem

Novelty:  0.0000744

Score:  0.975

Data Source:  Reactome,STRINGDB

KMT2A

Tchem

Family:  Epigenetic

Novelty:  0.00192554

Score:  0.969

Data Source:  STRINGDB

JUND

Tbio

Family:  TF

Novelty:  0.00277701

Score:  0.957

Data Source:  STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

Score:  0.954

Data Source:  STRINGDB

Publication Statistics

PubMed Score  1933.11

PubMed score by year

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PubTator Score  1599.75

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Disease mutation
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
gout
mathematical ability
mean reticulocyte volume
smoking status measurement
urate measurement
uric acid measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype