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Tbio
F2RL2
Proteinase-activated receptor 3

Protein Summary
Description
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296641
  • ENSP00000296641
  • ENSG00000164220
  • ENST00000504899
  • ENSP00000426703

Symbol
  • PAR3
  • PAR3
  • PAR-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
molecular function
0.73
virus perturbation
0.64
microRNA
0.63
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (219)
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.984
Data Source:  Reactome,STRINGDB
PARD6A
Tbio
Novelty:  0.05667035
Score:  0.96
Data Source:  STRINGDB
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
Score:  0.947
Data Source:  Reactome,STRINGDB
F2RL3
Tchem
Family:  GPCR
Novelty:  0.01953308
Score:  0.943
Data Source:  Reactome,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
Score:  0.932
Data Source:  STRINGDB
PTGFR
Tclin
Family:  GPCR
Novelty:  0.00560908
Score:  0.924
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.918
Data Source:  STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.915
Data Source:  STRINGDB
FFAR4
Tchem
Family:  GPCR
Novelty:  0.00439747
Score:  0.914
Data Source:  STRINGDB
FFAR1
Tchem
Family:  GPCR
Novelty:  0.00271782
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
PRSS1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
7
10
99.7
platelet count
2
3
4
97.8
reticulocyte count
3
3
7
95.7
reticulocyte measurement
2
3
6
94.7
proteinase-activated receptor 1 measurement
1
1
1
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
99.7
platelet count
4
97.8
reticulocyte count
7
95.7
reticulocyte measurement
6
94.7
proteinase-activated receptor 1 measurement
1
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II thrombin receptor like 2
VGNC:6870
100614246
Macaque
coagulation factor II thrombin receptor like 2
707260
Mouse
MGI:1298208
14064
Rat
RGD:620871
29636
Dog
coagulation factor II thrombin receptor like 2
VGNC:53169
607963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II thrombin receptor like 2
Macaque
coagulation factor II thrombin receptor like 2
Mouse
Rat
Dog
coagulation factor II thrombin receptor like 2
Publication Statistics
PubMed Score 4.00
PubMed score by year
PubTator Score 77.08
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title