F2RL2
Proteinase-activated receptor 3
Protein Summary
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
- ENST00000296641
- ENSP00000296641
- ENSG00000164220
- ENST00000504899
- ENSP00000426703
- PAR3
- PAR3
- PAR-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
molecular function | 0.73 | ||
virus perturbation | 0.64 | ||
microRNA | 0.63 | ||
hub protein | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (219)
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (25)
Reactome (10)
KEGG (2)
PathwayCommons (8)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 7 | 10 | 99.7 | |||||
platelet count | 2 | 3 | 4 | 97.8 | |||||
reticulocyte count | 3 | 3 | 7 | 95.7 | |||||
reticulocyte measurement | 2 | 3 | 6 | 94.7 | |||||
proteinase-activated receptor 1 measurement | 1 | 1 | 1 | 80.6 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 10 | 99.7 | |||||
platelet count | 4 | 97.8 | |||||
reticulocyte count | 7 | 95.7 | |||||
reticulocyte measurement | 6 | 94.7 | |||||
proteinase-activated receptor 1 measurement | 1 | 80.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor II thrombin receptor like 2 | VGNC:6870 | 100614246 | |||||
Macaque | coagulation factor II thrombin receptor like 2 | 707260 | ||||||
Mouse | MGI:1298208 | 14064 | ||||||
Rat | RGD:620871 | 29636 | ||||||
Dog | coagulation factor II thrombin receptor like 2 | VGNC:53169 | 607963 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor II thrombin receptor like 2 | |||||
Macaque | coagulation factor II thrombin receptor like 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | coagulation factor II thrombin receptor like 2 | |||||
Publication Statistics
PubMed Score 4.00
PubMed score by year
PubTator Score 77.08
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (62)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
|---|