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Tbio
AGRP
Agouti-related protein

Protein Classes
Protein Summary
Description
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290953
  • ENSP00000290953
  • ENSG00000159723

Symbol
  • AGRT
  • ART
  • ART
  • AGRT
  • ASIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
gene perturbation
0.69
phenotype
0.62
biological term
0.55
cellular component
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.25   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.25   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2
2
88.7
high density lipoprotein cholesterol measurement
1
2
2
88.5
heel bone mineral density
2
1
2
80.4
mean platelet volume
2
2
2
79
mean corpuscular volume
1
1
1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
88.7
high density lipoprotein cholesterol measurement
2
88.5
heel bone mineral density
2
80.4
mean platelet volume
2
79
mean corpuscular volume
1
71.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
agouti related neuropeptide
VGNC:5668
741961
Mouse
MGI:892013
11604
Rat
RGD:2068
25582
Dog
agouti related neuropeptide
VGNC:37717
611198
Horse
agouti related neuropeptide
VGNC:15171
100066082
Species
Name
OMA
EggNOG
Inparanoid
Chimp
agouti related neuropeptide
Mouse
Rat
Dog
agouti related neuropeptide
Horse
agouti related neuropeptide
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00253-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (99)
1 – 10 of 99
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999998091
p_ni:  0.000001909
Data Source:  BioPlex
TK1
Tchem
Family:  Kinase
Novelty:  0.00139343
p_int:  0.999867076
p_ni:  0.000132924
Score:  0.392
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.995231551
p_ni:  0.004768449
Score:  0.18
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.928650658
p_ni:  0.071328097
p_wrong:  0.000021244
Data Source:  BioPlex
NHLRC3
Tdark
Novelty:  1.23813202
p_int:  0.887225308
p_ni:  0.112668822
p_wrong:  0.000105871
Score:  0.309
Data Source:  BioPlex,STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
p_int:  0.877034491
p_ni:  0.122965509
Score:  0.228
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.808135802
p_ni:  0.191864198
Score:  0.185
Data Source:  BioPlex,STRINGDB
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.762828033
p_ni:  0.237171947
p_wrong:  2e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
MC4R
Tclin
Family:  GPCR
Novelty:  0.00091593
Score:  0.995
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.993
Data Source:  STRINGDB
Publication Statistics
PubMed Score  731.25

PubMed score by year
PubTator Score  238.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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