ATOX1
Copper transport protein ATOX1
Protein Summary
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
- ENST00000313115
- ENSP00000316854
- ENSG00000177556
- ENST00000522710
- ENSP00000429814
- ENST00000524142
- ENSP00000430598
- HAH1
- ATX1
- HAH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
kinase perturbation | 0.95 | ||
disease perturbation | 0.87 | ||
histone modification site profile | 0.78 | ||
molecular function | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.26 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 212 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.26 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 212 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0