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Tbio
SIRPB1
Signal-regulatory protein beta-1

Protein Summary
Description
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381603
  • ENSP00000371016
  • ENSG00000101307
  • ENST00000381605
  • ENSP00000371018

Symbol
  • CD172b
  • SIRP-BETA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (21)
1 – 10 of 21
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.975
Data Source:  Reactome,STRINGDB
TMEM86B
Tbio
Family:  Enzyme
Novelty:  0.26982157
Score:  0.777
Data Source:  STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.729
Data Source:  STRINGDB
ATP10D
Tdark
Family:  Transporter
Novelty:  0.21272192
Score:  0.714
Data Source:  STRINGDB
CD300LB
Tbio
Novelty:  0.10587821
Score:  0.608
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.57
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.569
Data Source:  STRINGDB
ZNF506
Tdark
Family:  TF
Novelty:  9.84094643
Score:  0.558
Data Source:  STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
Score:  0.547
Data Source:  STRINGDB
TREM1
Tbio
Novelty:  0.00249253
Score:  0.527
Data Source:  STRINGDB
Pathways (7)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
DAP12 interactions
Immune System
Innate Immune System
Neutrophil degranulation
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
4
10
97.9
mean platelet volume
2
4
10
97.9
platelet crit
2
3
8
91.4
platelet crit
2
3
8
91.4
monocyte count
1
1
2
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
97.9
mean platelet volume
10
97.9
platelet crit
8
91.4
platelet crit
8
91.4
monocyte count
2
75.3
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Publication Statistics
PubMed Score 12.85
PubMed score by year
PubTator Score 12.71
PubTator score by year