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Tchem
BMPR1B
Bone morphogenetic protein receptor type-1B

Protein Summary
Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264568
  • ENSP00000264568
  • ENSG00000138696
  • ENST00000394931
  • ENSP00000378389
  • ENST00000440890
  • ENSP00000401907
  • ENST00000509540
  • ENSP00000421671
  • ENST00000512312
  • ENSP00000425444
  • ENST00000515059
  • ENSP00000426617

Symbol
  • ALK6
  • AMDD
  • BDA2
  • ALK-6
  • BDA1D
  • CDw293
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
biological process
0.89
small molecule
0.89
gene perturbation
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.16   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 606   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.16   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 606   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0