Tchem BMPR1B Bone morphogenetic protein receptor type-1B

Protein Summary

Description

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• O00238
• B2R953
• B4DSV1
• P78366
• BMP type-1B receptor

Gene Name

• BMPR1B

Ensembl ID

• ENST00000264568
• ENSP00000264568
• ENSG00000138696
• ENST00000394931
• ENSP00000378389
• ENST00000440890
• ENSP00000401907
• ENST00000509540
• ENSP00000421671
• ENST00000512312
• ENSP00000425444
• ENST00000515059
• ENSP00000426617

Symbol

• ALK6
• AMDD
• BDA2
• ALK-6
• BDA1D
• CDw293

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.92
biological process	0.89
small molecule	0.89
gene perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Bone Morphogenetic Protein Receptor Type-1b

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Bone Morphogenetic Protein Receptor Type-1b

Protein / Receptor / Cytokine Receptor / Tgf-beta Receptor / Bone Morphogenetic Protein Receptor Type-1b

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Stkr Family / Stkr Type 1 Subfamily / Bone Morphogenetic Protein Receptor Type-1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.16   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 606   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.16   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 606   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0