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Tbio
RNF103
E3 ubiquitin-protein ligase RNF103

Protein Summary
Description
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237455
  • ENSP00000237455
  • ENSG00000239305

Symbol
  • ZFP103
  • KF1
  • KF-1
  • HKF-1
  • ZFP103
  • ZFP-103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
cell type or tissue
0.71
PubMedID
0.71
virus perturbation
0.64
cell line
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
31
risky sexual behaviour measurement
1
1
1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
31
risky sexual behaviour measurement
1
17.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
E3 ubiquitin-protein ligase RNF103 [Source:RefSeq peptide;Acc:NP_001253506]
Mouse
MGI:109483
22644
Rat
RGD:620586
84508
Dog
ring finger protein 103
VGNC:45619
475761
Horse
ring finger protein 103
VGNC:22424
100052907
Species
Name
OMA
EggNOG
Inparanoid
Macaque
E3 ubiquitin-protein ligase RNF103 [Source:RefSeq peptide;Acc:NP_001253506]
Mouse
Rat
Dog
ring finger protein 103
Horse
ring finger protein 103
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00237-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Protein-Protein Interactions (45)
1 – 10 of 45
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.94
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.937
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.931
Data Source: STRINGDB
DERL2
Tbio
Novelty: 0.02479307
Score: 0.928
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.926
Data Source: STRINGDB
OS9
Tbio
Novelty: 0.01490339
Score: 0.923
Data Source: STRINGDB
SEL1L
Tbio
Novelty: 0.01198173
Score: 0.912
Data Source: STRINGDB
RAPSN
Tbio
Novelty: 0.00565077
Score: 0.802
Data Source: STRINGDB
RNF139
Tbio
Family: Enzyme
Novelty: 0.05828557
Score: 0.733
Data Source: STRINGDB
EGFL8
Tbio
Novelty: 0.01309625
Score: 0.704
Data Source: STRINGDB
Publication Statistics
PubMed Score  114.11

PubMed score by year
PubTator Score  28.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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