Tbio PSMD9 26S proteasome non-ATPase regulatory subunit 9

Protein Summary

Description

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O00233
• B2RD35
• G3V1Q6
• Q9BQ42

Gene Name

• PSMD9

Ensembl ID

• ENST00000537407
• ENSP00000445058
• ENSG00000110801
• ENST00000541212
• ENSP00000440485
• ENST00000542602
• ENSP00000443772

Symbol

• p27
• Rpn4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.96
interacting protein	0.84
histone modification site profile	0.77
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / 26s Proteasome Non-atpase Regulatory Subunit 9

DTO Classes

Protein / Enzyme Modulator / 26s Proteasome Non-atpase Regulatory Subunit 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.98   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.98   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0