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Tbio
PSMD9
26S proteasome non-ATPase regulatory subunit 9

Protein Classes
Protein Summary
Description
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537407
  • ENSP00000445058
  • ENSG00000110801
  • ENST00000541212
  • ENSP00000440485
  • ENST00000542602
  • ENSP00000443772

Symbol
  • p27
  • Rpn4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.96
interacting protein
0.84
histone modification site profile
0.77
transcription factor binding site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.93   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.93   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
5
9
99.1
blood metabolite measurement
1
1
1
70.5
urinary metabolite measurement
1
1
1
66
BMI-adjusted waist-hip ratio
1
1
1
49.5
waist-hip ratio
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.1
blood metabolite measurement
1
70.5
urinary metabolite measurement
1
66
BMI-adjusted waist-hip ratio
1
49.5
waist-hip ratio
1
48.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
proteasome 26S subunit, non-ATPase 9
701174
Mouse
MGI:1914401
67151
Rat
RGD:621110
161475
Dog
proteasome 26S subunit, non-ATPase 9
VGNC:52958
477467
Horse
proteasome 26S subunit, non-ATPase 9
VGNC:50963
100058668
Species
Name
OMA
EggNOG
Inparanoid
Macaque
proteasome 26S subunit, non-ATPase 9
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 9
Horse
proteasome 26S subunit, non-ATPase 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (154)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (245)
1 – 10 of 245
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999935923
p_ni:  0.000064077
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC6
Tbio
Family:  Enzyme
Novelty:  0.00168013
p_int:  0.996619446
p_ni:  0.003380554
Score:  0.999
Data Source:  BioPlex,STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
p_int:  0.985642993
p_ni:  0.014353548
p_wrong:  0.000003459
Score:  0.46
Data Source:  BioPlex,STRINGDB
ERI3
Tbio
Family:  Enzyme
Novelty:  0.08842487
p_int:  0.936261547
p_ni:  0.000016135
p_wrong:  0.063722318
Score:  0.322
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.757331396
p_ni:  0.2426686
p_wrong:  4e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
Score:  0.997
Data Source:  STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
Score:  0.997
Data Source:  STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
Score:  0.996
Data Source:  STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
Score:  0.996
Data Source:  STRINGDB
PSMD2
Tbio
Family:  Enzyme
Novelty:  0.03530762
Score:  0.996
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.93

PubMed score by year
PubTator Score  31.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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