Tbio PSMD9 26S proteasome non-ATPase regulatory subunit 9

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / 26S Proteasome Non-atpase Regulatory Subunit 9

DTO Classes

Protein / Enzyme Modulator / 26S Proteasome Non-atpase Regulatory Subunit 9

Protein Summary

Description

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O00233
• B2RD35
• G3V1Q6
• Q9BQ42

Gene Name

• PSMD9

Ensembl ID

• ENST00000537407
• ENSP00000445058
• ENSG00000110801
• ENST00000541212
• ENSP00000440485
• ENST00000542602
• ENSP00000443772

Symbol

• p27
• Rpn4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.96
interacting protein	0.84
histone modification site profile	0.77
transcription factor binding site profile	0.74

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.93   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.93   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	7	5	9		99.1
blood metabolite measurement	EFO_0005664	1	1	1		70.5
urinary metabolite measurement	EFO_0005116	1	1	1		66
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		49.5
waist-hip ratio	EFO_0004343	1	1	1		48.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	9		99.1
blood metabolite measurement	EFO_0005664	1		70.5
urinary metabolite measurement	EFO_0005116	1		66
BMI-adjusted waist-hip ratio	EFO_0007788	1		49.5
waist-hip ratio	EFO_0004343	1		48.5

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	proteasome 26S subunit, non-ATPase 9		701174
Mouse	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	MGI:1914401	67151
Rat	proteasome 26S subunit, non-ATPase 9	RGD:621110	161475
Dog	proteasome 26S subunit, non-ATPase 9	VGNC:52958	477467
Horse	proteasome 26S subunit, non-ATPase 9	VGNC:50963	100058668

Species	Name	OMA	EggNOG	Inparanoid
Macaque	proteasome 26S subunit, non-ATPase 9
Mouse	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Rat	proteasome 26S subunit, non-ATPase 9
Dog	proteasome 26S subunit, non-ATPase 9
Horse	proteasome 26S subunit, non-ATPase 9

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O00233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (154)

Reactome (148)

PathwayCommons (4)

WikiPathways (2)

ABC transporter disorders (R-HSA-5619084)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC transporter disorders	78 targets	R-HSA-5619084
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
ABC transporter disorders	78 targets	R-HSA-5619084
ABC-family proteins mediated transport	104 targets	R-HSA-382556
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Gene Ontology Terms (15)

Functions (2)

Components (6)

Processes (7)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
bHLH transcription factor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
transcription coactivator activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Protein-Protein Interactions (245)

Explore Interacting Targets

1 – 10 of 245

• See Interactions on String-DB

PSMC3

Tbio

Family:  Enzyme

Novelty:  0.04026019

p_int:  0.999935923

p_ni:  0.000064077

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMC6

Tbio

Family:  Enzyme

Novelty:  0.00168013

p_int:  0.996619446

p_ni:  0.003380554

Score:  0.999

Data Source:  BioPlex,STRINGDB

AKT2

Tchem

Family:  Kinase

Novelty:  0.00167027

p_int:  0.985642993

p_ni:  0.014353548

p_wrong:  0.000003459

Score:  0.46

Data Source:  BioPlex,STRINGDB

ERI3

Tbio

Family:  Enzyme

Novelty:  0.08842487

p_int:  0.936261547

p_ni:  0.000016135

p_wrong:  0.063722318

Score:  0.322

Data Source:  BioPlex,STRINGDB

CCDC40

Tbio

Novelty:  0.06726469

p_int:  0.757331396

p_ni:  0.2426686

p_wrong:  4e-9

Score:  0.795

Data Source:  BioPlex,STRINGDB

PSMC5

Tbio

Family:  Enzyme

Novelty:  0.01634039

Score:  0.997

Data Source:  STRINGDB

PSMC4

Tchem

Family:  Enzyme

Novelty:  0.01717597

Score:  0.997

Data Source:  STRINGDB

PSMD12

Tbio

Family:  Enzyme

Novelty:  0.03178037

Score:  0.996

Data Source:  STRINGDB

PSMD1

Tbio

Family:  Enzyme

Novelty:  0.02168311

Score:  0.996

Data Source:  STRINGDB

PSMD2

Tbio

Family:  Enzyme

Novelty:  0.03530762

Score:  0.996

Data Source:  STRINGDB

Publication Statistics

PubMed Score  49.93

PubMed score by year

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PubTator Score  31.64

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Chaperone
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GWAS Trait Find Similar Targets

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blood metabolite measurement
BMI-adjusted waist-hip ratio
body mass index
C-reactive protein measurement
cognitive function measurement
high density lipoprotein cholesterol measurement
liver fibrosis measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume