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Tbio
PSMD9
26S proteasome non-ATPase regulatory subunit 9

Protein Classes
PANTHER Classes Protein / Enzyme Modulator / 26S Proteasome Non-atpase Regulatory Subunit 9
DTO ClassesProtein / Enzyme Modulator / 26S Proteasome Non-atpase Regulatory Subunit 9
Protein Summary
Description
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537407
  • ENSP00000445058
  • ENSG00000110801
  • ENST00000541212
  • ENSP00000440485
  • ENST00000542602
  • ENSP00000443772

Symbol
  • p27
  • Rpn4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.96
interacting protein
0.84
histone modification site profile
0.77
transcription factor binding site profile
0.74


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.22   (req: < 5)
View Publications
Gene RIFs: 41   (req: <= 3)
View Gene RIFs
Antibodies: 257   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.22   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
EFO_0005116
1
1
1
78
cognitive function measurement
EFO_0008354
1
1
1
52
self reported educational attainment
EFO_0004784
1
1
1
43.8
Items per page:
1 – 3 of 3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
EFO_0005116
1
78
cognitive function measurement
EFO_0008354
1
52
self reported educational attainment
EFO_0004784
1
43.8
Pathways (154)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
78 targets
R-HSA-5619084
Reactome
ABC-family proteins mediated transport
104 targets
R-HSA-382556
Reactome
APC/C-mediated degradation of cell cycle proteins
87 targets
R-HSA-174143
Reactome
APC/C:Cdc20 mediated degradation of Securin
68 targets
R-HSA-174154
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
76 targets
R-HSA-176409
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
78 targets
R-HSA-5619084
ABC-family proteins mediated transport
104 targets
R-HSA-382556
APC/C-mediated degradation of cell cycle proteins
87 targets
R-HSA-174143
APC/C:Cdc20 mediated degradation of Securin
68 targets
R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins
76 targets
R-HSA-176409
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
bHLH transcription factor binding
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
transcription coactivator activity
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (245)
1 – 10 of 245
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.999935923
p_ni: 0.000064077
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMC6
Tbio
Family: Enzyme
Novelty: 0.00168013
p_int: 0.996619446
p_ni: 0.003380554
Score: 0.999
Data Source: BioPlex,STRINGDB
AKT2
Tchem
Family: Kinase
Novelty: 0.00167027
p_int: 0.985642993
p_ni: 0.014353548
p_wrong: 0.000003459
Score: 0.46
Data Source: BioPlex,STRINGDB
ERI3
Tbio
Family: Enzyme
Novelty: 0.08842487
p_int: 0.936261547
p_ni: 0.000016135
p_wrong: 0.063722318
Score: 0.322
Data Source: BioPlex,STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
p_int: 0.757331396
p_ni: 0.2426686
p_wrong: 4e-9
Score: 0.795
Data Source: BioPlex,STRINGDB
PSMC5
Tbio
Family: Enzyme
Novelty: 0.01634039
Score: 0.997
Data Source: STRINGDB
PSMC4
Tbio
Family: Enzyme
Novelty: 0.01717597
Score: 0.997
Data Source: STRINGDB
PSMD12
Tbio
Family: Enzyme
Novelty: 0.03178037
Score: 0.996
Data Source: STRINGDB
PSMD1
Tbio
Family: Enzyme
Novelty: 0.02168311
Score: 0.996
Data Source: STRINGDB
PSMD2
Tbio
Family: Enzyme
Novelty: 0.03530762
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.22

PubMed score by year
PubTator Score  31.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer