Tbio PSMD9 26S proteasome non-ATPase regulatory subunit 9

Protein Summary

Description

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O00233
• B2RD35
• G3V1Q6
• Q9BQ42

Gene Name

• PSMD9

Ensembl ID

• ENST00000537407
• ENSP00000445058
• ENSG00000110801
• ENST00000541212
• ENSP00000440485
• ENST00000542602
• ENSP00000443772

Symbol

• p27
• Rpn4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.96
interacting protein	0.84
histone modification site profile	0.77
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / 26s Proteasome Non-atpase Regulatory Subunit 9

DTO Classes

Protein / Enzyme Modulator / 26s Proteasome Non-atpase Regulatory Subunit 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.93   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.93   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (245)

Explore Interacting Targets

1 – 10 of 245

• See Interactions on String-DB

PSMC3

Tbio

Family:  Enzyme

Novelty:  0.04026019

p_int:  0.999935923

p_ni:  0.000064077

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMC6

Tbio

Family:  Enzyme

Novelty:  0.00168013

p_int:  0.996619446

p_ni:  0.003380554

Score:  0.999

Data Source:  BioPlex,STRINGDB

AKT2

Tchem

Family:  Kinase

Novelty:  0.00167027

p_int:  0.985642993

p_ni:  0.014353548

p_wrong:  0.000003459

Score:  0.46

Data Source:  BioPlex,STRINGDB

ERI3

Tbio

Family:  Enzyme

Novelty:  0.08842487

p_int:  0.936261547

p_ni:  0.000016135

p_wrong:  0.063722318

Score:  0.322

Data Source:  BioPlex,STRINGDB

CCDC40

Tbio

Novelty:  0.06726469

p_int:  0.757331396

p_ni:  0.2426686

p_wrong:  4e-9

Score:  0.795

Data Source:  BioPlex,STRINGDB

PSMC5

Tbio

Family:  Enzyme

Novelty:  0.01634039

Score:  0.997

Data Source:  STRINGDB

PSMC4

Tchem

Family:  Enzyme

Novelty:  0.01717597

Score:  0.997

Data Source:  STRINGDB

PSMD12

Tbio

Family:  Enzyme

Novelty:  0.03178037

Score:  0.996

Data Source:  STRINGDB

PSMD1

Tbio

Family:  Enzyme

Novelty:  0.02168311

Score:  0.996

Data Source:  STRINGDB

PSMD2

Tbio

Family:  Enzyme

Novelty:  0.03530762

Score:  0.996

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (154)

Reactome (148)

PathwayCommons (4)

WikiPathways (2)

ABC transporter disorders (R-HSA-5619084)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC transporter disorders	78 targets	R-HSA-5619084
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
ABC transporter disorders	78 targets	R-HSA-5619084
ABC-family proteins mediated transport	104 targets	R-HSA-382556
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (2)

Components (6)

Processes (7)

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1 – 2 of 2

GO Term	Evidence	Assigned by
bHLH transcription factor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
transcription coactivator activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	7	5	9		99.1
blood metabolite measurement	EFO_0005664	1	1	1		70.5
urinary metabolite measurement	EFO_0005116	1	1	1		66
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		49.5
waist-hip ratio	EFO_0004343	1	1	1		48.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	9		99.1
blood metabolite measurement	EFO_0005664	1		70.5
urinary metabolite measurement	EFO_0005116	1		66
BMI-adjusted waist-hip ratio	EFO_0007788	1		49.5
waist-hip ratio	EFO_0004343	1		48.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chaperone
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
BMI-adjusted waist-hip ratio
body mass index
C-reactive protein measurement
cognitive function measurement
high density lipoprotein cholesterol measurement
liver fibrosis measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	proteasome 26S subunit, non-ATPase 9		701174
Mouse	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	MGI:1914401	67151
Rat	proteasome 26S subunit, non-ATPase 9	RGD:621110	161475
Dog	proteasome 26S subunit, non-ATPase 9	VGNC:52958	477467
Horse	proteasome 26S subunit, non-ATPase 9	VGNC:50963	100058668

Species	Name	OMA	EggNOG	Inparanoid
Macaque	proteasome 26S subunit, non-ATPase 9
Mouse	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Rat	proteasome 26S subunit, non-ATPase 9
Dog	proteasome 26S subunit, non-ATPase 9
Horse	proteasome 26S subunit, non-ATPase 9

Publication Statistics

PubMed Score 49.93

PubMed score by year

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PubTator Score 31.64

PubTator score by year

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Related Publications

Text Mined References (90)

GeneRif Annotations (41)

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PMID	Year	Title