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Tbio
PSMD12
26S proteasome non-ATPase regulatory subunit 12

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356126
  • ENSP00000348442
  • ENSG00000197170
  • ENST00000357146
  • ENSP00000349667

Symbol
  • p55
  • Rpn5
  • STISS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
biological process
0.98
virus perturbation
0.98
kinase perturbation
0.93


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (360)
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC92
Tbio
Novelty:  0.32125749
p_int:  0.999999513
p_ni:  4.87e-7
Score:  0.827
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999989549
p_ni:  0.000010451
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
p_int:  0.999932636
p_ni:  0.000067364
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
p_int:  0.999916314
p_ni:  0.000083686
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.999904277
p_ni:  0.000095723
Score:  0.999
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.999884102
p_ni:  0.000115898
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD14
Tchem
Family:  Enzyme
Novelty:  0.01019285
p_int:  0.999840792
p_ni:  0.000159208
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
p_int:  0.999568462
p_ni:  0.000431538
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
p_int:  0.999105221
p_ni:  0.000894779
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (160)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
79.1
glomerular filtration rate
1
1
1
39.6
waist-hip ratio
1
2
2
32.7
BMI-adjusted waist-hip ratio
2
2
3
31.3
inflammatory biomarker measurement
1
1
0
16959
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
79.1
glomerular filtration rate
1
39.6
waist-hip ratio
2
32.7
BMI-adjusted waist-hip ratio
3
31.3
inflammatory biomarker measurement
0
16959
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 12
VGNC:9543
454836
Macaque
proteasome 26S subunit, non-ATPase 12
718756
Mouse
MGI:1914247
66997
Rat
RGD:1359305
287772
Dog
proteasome 26S subunit, non-ATPase 12
VGNC:45108
480465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 12
Macaque
proteasome 26S subunit, non-ATPase 12
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 12
Publication Statistics
PubMed Score 35.71
PubMed score by year
PubTator Score 10.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title