Tbio PSMD12 26S proteasome non-ATPase regulatory subunit 12

Protein Summary

Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• O00232
• A6NP15
• Q53HA2
• Q6P053

Gene Name

• PSMD12

Ensembl ID

• ENST00000356126
• ENSP00000348442
• ENSG00000197170
• ENST00000357146
• ENSP00000349667

Symbol

• p55
• Rpn5
• STISS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
biological process	0.98
virus perturbation	0.98
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / 26s Proteasome Non-atpase Regulatory Subunit 12

DTO Classes

Protein / Enzyme Modulator / 26s Proteasome Non-atpase Regulatory Subunit 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (360)

Explore Interacting Targets

1 – 10 of 360

• See Interactions on String-DB

PSMD7

Tbio

Family:  Enzyme

Novelty:  0.03090292

p_int:  0.999999941

p_ni:  5.9e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

CCDC92

Tbio

Novelty:  0.32125749

p_int:  0.999999513

p_ni:  4.87e-7

Score:  0.827

Data Source:  BioPlex,STRINGDB

PSMC5

Tbio

Family:  Enzyme

Novelty:  0.01634039

p_int:  0.999989549

p_ni:  0.000010451

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMD11

Tbio

Family:  Enzyme

Novelty:  0.02148951

p_int:  0.999932636

p_ni:  0.000067364

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMD6

Tbio

Family:  Enzyme

Novelty:  0.04419339

p_int:  0.999916314

p_ni:  0.000083686

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMD13

Tbio

Family:  Enzyme

Novelty:  0.04204417

p_int:  0.999904277

p_ni:  0.000095723

Score:  0.999

Data Source:  BioPlex,STRINGDB

ADRM1

Tbio

Novelty:  0.01545209

p_int:  0.999884102

p_ni:  0.000115898

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMD14

Tchem

Family:  Enzyme

Novelty:  0.01019285

p_int:  0.999840792

p_ni:  0.000159208

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMD1

Tbio

Family:  Enzyme

Novelty:  0.02168311

p_int:  0.999568462

p_ni:  0.000431538

Score:  0.999

Data Source:  BioPlex,STRINGDB

PSMC1

Tbio

Family:  Enzyme

Novelty:  0.04631888

p_int:  0.999105221

p_ni:  0.000894779

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (160)

Reactome (149)

KEGG (2)

PathwayCommons (6)

WikiPathways (3)

ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 149

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC transporter disorders	78 targets	R-HSA-5619084
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
ABC transporter disorders	78 targets	R-HSA-5619084
ABC-family proteins mediated transport	104 targets	R-HSA-382556
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Components (13)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 10 of 13

GO Term	Evidence	Assigned by
proteasome complex	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
membrane	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
cytoplasm	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nuclear proteasome complex	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
proteasome regulatory particle, lid subcomplex	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
proteasome accessory complex	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
cytosol	Traceable Author Statement (TAS)	Reactome
extracellular region	Traceable Author Statement (TAS)	Reactome
ficolin-1-rich granule lumen	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	4	2	4		79.1
glomerular filtration rate	EFO_0005208	1	1	1		39.6
waist-hip ratio	EFO_0004343	1	2	2		32.7
BMI-adjusted waist-hip ratio	EFO_0007788	2	2	3		31.3
inflammatory biomarker measurement	EFO_0004872	1	1	0	16959	24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	4		79.1
glomerular filtration rate	EFO_0005208	1		39.6
waist-hip ratio	EFO_0004343	2		32.7
BMI-adjusted waist-hip ratio	EFO_0007788	3		31.3
inflammatory biomarker measurement	EFO_0004872	0	16959	24.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Isopeptide bond
Mental retardation
Polymorphism
Proteasome
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
comparative body size at age 10, self-reported
glomerular filtration rate
inflammatory biomarker measurement
sex hormone-binding globulin measurement
waist-hip ratio

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	proteasome 26S subunit, non-ATPase 12	VGNC:9543	454836
Macaque	proteasome 26S subunit, non-ATPase 12		718756
Mouse	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	MGI:1914247	66997
Rat	proteasome 26S subunit, non-ATPase 12	RGD:1359305	287772
Dog	proteasome 26S subunit, non-ATPase 12	VGNC:45108	480465

Species	Name	OMA	EggNOG	Inparanoid
Chimp	proteasome 26S subunit, non-ATPase 12
Macaque	proteasome 26S subunit, non-ATPase 12
Mouse	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Rat	proteasome 26S subunit, non-ATPase 12
Dog	proteasome 26S subunit, non-ATPase 12

Publication Statistics

PubMed Score 35.71

PubMed score by year

Reset Zoom

PubTator Score 10.49

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (47)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title