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Tbio
PSMD11
26S proteasome non-ATPase regulatory subunit 11

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261712
  • ENSP00000261712
  • ENSG00000108671
  • ENST00000457654
  • ENSP00000393185
  • ENST00000649012
  • ENSP00000497128

Symbol
  • S9
  • Rpn6
  • p44.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.99
hub protein
0.98
transcription factor perturbation
0.96
virus perturbation
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.9   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.9   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (401)
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.999932636
p_ni:  0.000067364
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.999617614
p_ni:  0.000382386
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.998539545
p_ni:  0.001460455
Score:  0.999
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.997476829
p_ni:  0.002523171
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.996865759
p_ni:  0.003134241
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.995244769
p_ni:  0.004755231
Score:  0.995
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.994979778
p_ni:  0.005020222
Score:  0.991
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.992124287
p_ni:  0.007875713
Score:  0.768
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.988174874
p_ni:  0.011825126
Data Source:  BioPlex
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.987385571
p_ni:  0.012614429
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (158)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
55.8
systolic blood pressure
1
1
1
42.3
emphysema pattern measurement
1
1
1
21.5
1
1
0
1.1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
55.8
systolic blood pressure
1
42.3
emphysema pattern measurement
1
21.5
0
1.1
2
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 11
VGNC:12618
454574
Macaque
proteasome 26S subunit, non-ATPase 11
717953
Mouse
MGI:1916327
69077
Rat
RGD:1306450
303353
Dog
proteasome 26S subunit, non-ATPase 11
VGNC:45107
480610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 11
Macaque
proteasome 26S subunit, non-ATPase 11
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 11
Publication Statistics
PubMed Score 47.90
PubMed score by year
PubTator Score 11.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title