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Tbio
CORT
Cortistatin

Protein Summary
Description
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs. This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377049
  • ENSP00000366248
  • ENSG00000241563

Symbol
  • CST-14
  • CST-17
  • CST-29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
small molecule perturbation
0.62
cell line
0.55
gene perturbation
0.52
metabolite
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.11   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.11   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cortistatin
VGNC:508
100534603
Mouse
MGI:109538
12854
Cow
cortistatin
781658
Pig
cortistatin
100526112
Opossum
cortistatin
103104622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cortistatin
Mouse
Cow
cortistatin
Pig
cortistatin
Opossum
cortistatin
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (282)
1 – 10 of 282
AP1S2
Tbio
Novelty: 0.01413503
p_int: 0.96314926
p_ni: 0.000125342
p_wrong: 0.036725398
Score: 0.214
Data Source: BioPlex,STRINGDB
MB
Tbio
Novelty: 0.00008405
p_int: 0.897240724
p_ni: 0.102654758
p_wrong: 0.000104518
Score: 0.685
Data Source: BioPlex,STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.983
Data Source: STRINGDB
SSTR5
Tclin
Family: GPCR
Novelty: 0.00568309
Score: 0.973
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.972
Data Source: STRINGDB
SSTR1
Tclin
Family: GPCR
Novelty: 0.00588024
Score: 0.97
Data Source: STRINGDB
SSTR2
Tclin
Family: GPCR
Novelty: 0.00200092
Score: 0.969
Data Source: STRINGDB
SSTR4
Tclin
Family: GPCR
Novelty: 0.01528237
Score: 0.969
Data Source: STRINGDB
SSTR3
Tclin
Family: GPCR
Novelty: 0.00899073
Score: 0.968
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  132.11

PubMed score by year
PubTator Score  401.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer