Tbio CORT Cortistatin

Protein Summary

Description

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs. This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• O00230
• Q5T6G0
• Q6UX11

Gene Name

• CORT

Ensembl ID

• ENST00000377049
• ENSP00000366248
• ENSG00000241563

Symbol

• CST-14
• CST-17
• CST-29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.62
small molecule perturbation	0.62
cell line	0.55
gene perturbation	0.52
metabolite	0.45

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Cortistatin

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Cortistatin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.88   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 47   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.88   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0