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Tbio
NFKBIE
NF-kappa-B inhibitor epsilon

Protein Summary
Description
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275015
  • ENSP00000275015
  • ENSG00000146232

Symbol
  • IKBE
  • IKBE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
hub protein
0.94
gene perturbation
0.77
tissue sample
0.74
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.06   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 419   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.06   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
REL
Tbio
Family:  TF
Novelty:  0.00038265
p_int:  0.999999819
p_ni:  1.59e-7
p_wrong:  2.2e-8
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
RELB
Tbio
Family:  TF
Novelty:  0.00216805
p_int:  0.999998004
p_ni:  5.4e-8
p_wrong:  0.000001943
Score:  0.945
Data Source:  BioPlex,STRINGDB
C2orf27B
Tdark
Novelty:  4.24242424
p_int:  0.999732853
p_ni:  0.000055496
p_wrong:  0.000211651
Score:  0.485
Data Source:  BioPlex,STRINGDB
C2orf27A
Tdark
Novelty:  2.91059359
p_int:  0.829078685
p_ni:  0.000008379
p_wrong:  0.170912936
Data Source:  BioPlex
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.966
Data Source:  Reactome,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.959
Data Source:  Reactome,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.951
Data Source:  Reactome,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.95
Data Source:  Reactome,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.948
Data Source:  Reactome,STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
Score:  0.946
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (27)
Activation of NF-kappaB in B cells (R-HSA-1169091)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Reactome
Immune System
Reactome
Signaling by the B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Downstream signaling events of B Cell Receptor (BCR)
Immune System
Signaling by the B Cell Receptor (BCR)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
85
mean corpuscular volume
1
2
2
83.5
4
2
3
1.2
76.8
monocyte percentage of leukocytes
2
1
2
70.5
monocyte count
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
85
mean corpuscular volume
2
83.5
3
1.2
76.8
monocyte percentage of leukocytes
2
70.5
monocyte count
1
59.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor epsilon
VGNC:8173
462730
Macaque
NFKB inhibitor epsilon
702498
Mouse
MGI:1194908
18037
Rat
RGD:735070
316241
Dog
NFKB inhibitor epsilon
102155642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor epsilon
Macaque
NFKB inhibitor epsilon
Mouse
Rat
Dog
NFKB inhibitor epsilon
Publication Statistics
PubMed Score 42.06
PubMed score by year
PubTator Score 14.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title