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Tclin
NDUFS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313468
  • ENSP00000315774
  • ENSG00000110717

Symbol
  • TYKY
  • CI-23k
  • CI23KD
  • MC1DN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.91
transcription factor perturbation
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S8
VGNC:50384
451375
Macaque
NADH:ubiquinone oxidoreductase core subunit S8
710845
Mouse
MGI:2385079
225887
Rat
RGD:1309436
293652
Dog
NADH:ubiquinone oxidoreductase core subunit S8
VGNC:51883
610413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S8
Macaque
NADH:ubiquinone oxidoreductase core subunit S8
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit S8
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00217-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (241)
1 – 10 of 241
NDUFAF4
Tclin
Family: Enzyme
Novelty: 0.10799507
p_int: 0.999853928
p_ni: 0.000146072
Score: 0.964
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999396382
p_ni: 0.000603618
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999115699
p_ni: 0.000884301
Score: 0.994
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.994923598
p_ni: 0.005076402
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.977552836
p_ni: 0.022447164
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA13
Tclin
Family: Enzyme
Novelty: 0.01605077
p_int: 0.95241163
p_ni: 0.04758837
Score: 0.999
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.905794663
p_ni: 0.094205337
Score: 0.987
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.860484261
p_ni: 0.139515739
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.813697435
p_ni: 0.186302565
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.80957515
p_ni: 0.190424849
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  38.47

PubMed score by year
PubTator Score  17.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer