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Tchem
LGALS8
Galectin-8

Protein Summary
Description
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341872
  • ENSP00000342139
  • ENSG00000116977
  • ENST00000352231
  • ENSP00000309576
  • ENST00000366584
  • ENSP00000355543
  • ENST00000450372
  • ENSP00000408657
  • ENST00000526589
  • ENSP00000435460
  • ENST00000526634
  • ENSP00000437040
  • ENST00000527974
  • ENSP00000431398

Symbol
  • Gal-8
  • PCTA1
  • PCTA-1
  • Po66-CBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.99
disease perturbation
0.96
tissue sample
0.79
cell type or tissue
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.04   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.04   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
65.6
platelet crit
1
1
1
61.4
autoimmune thyroid disease
1
1
0
1.1
49.5
total cholesterol measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
65.6
platelet crit
1
61.4
autoimmune thyroid disease
0
1.1
49.5
total cholesterol measurement
1
36.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galectin 8
VGNC:10028
743841
Macaque
galectin 8
710375
Mouse
MGI:1928481
56048
Rat
RGD:621272
116641
Dog
galectin 8
VGNC:42650
479193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galectin 8
Macaque
galectin 8
Mouse
Rat
Dog
galectin 8
Protein Structure (29 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00214-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 29
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (125)
1 – 10 of 125
CSPG4
Tbio
Novelty:  0.0038499
p_int:  0.999999973
p_ni:  2.2e-8
p_wrong:  5e-9
Data Source:  BioPlex
PTPRJ
Tbio
Family:  Enzyme
Novelty:  0.00786921
p_int:  0.999999965
p_ni:  1.3e-8
p_wrong:  2.2e-8
Data Source:  BioPlex
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999999939
p_ni:  3e-8
p_wrong:  3.1e-8
Data Source:  BioPlex
ITGA5
Tbio
Novelty:  0.00285802
p_int:  0.999999793
p_ni:  1.99e-7
p_wrong:  8e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
ITGA1
Tbio
Novelty:  0.00545805
p_int:  0.999999656
p_ni:  8.4e-8
p_wrong:  2.6e-7
Score:  0.333
Data Source:  BioPlex,STRINGDB
SLC12A6
Tbio
Family:  Transporter
Novelty:  0.0132619
p_int:  0.999999491
p_ni:  5.08e-7
p_wrong:  1e-9
Data Source:  BioPlex
ITGA2
Tbio
Novelty:  0.0013482
p_int:  0.999999167
p_ni:  8.32e-7
Data Source:  BioPlex
CLCN3
Tchem
Family:  IC
Novelty:  0.00416196
p_int:  0.999999091
p_ni:  9.09e-7
Data Source:  BioPlex
ABCC4
Tchem
Family:  Transporter
Novelty:  0.00208051
p_int:  0.999997166
p_ni:  0.000002834
Data Source:  BioPlex
SDK1
Tbio
Novelty:  0.05094526
p_int:  0.999996565
p_ni:  0.00000155
p_wrong:  0.000001885
Score:  0.201
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  190.04

PubMed score by year
PubTator Score  113.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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