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Tchem
LGALS8
Galectin-8

Protein Summary
Description
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341872
  • ENSP00000342139
  • ENSG00000116977
  • ENST00000352231
  • ENSP00000309576
  • ENST00000366584
  • ENSP00000355543
  • ENST00000450372
  • ENSP00000408657
  • ENST00000526589
  • ENSP00000435460
  • ENST00000526634
  • ENSP00000437040
  • ENST00000527974
  • ENSP00000431398

Symbol
  • Gal-8
  • PCTA1
  • PCTA-1
  • Po66-CBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.99
disease perturbation
0.96
tissue sample
0.79
cell type or tissue
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.8   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.8   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0