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Tbio
APBB1
Amyloid-beta A4 precursor protein-binding family B member 1

Protein Summary
Description
Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). The protein encoded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299402
  • ENSP00000299402
  • ENSG00000166313
  • ENST00000311051
  • ENSP00000311912
  • ENST00000530885
  • ENSP00000433338
  • ENST00000608394
  • ENSP00000476442
  • ENST00000608645
  • ENSP00000476646
  • ENST00000608655
  • ENSP00000476846
  • ENST00000608704
  • ENSP00000476871
  • ENST00000609331
  • ENSP00000477069
  • ENST00000609360
  • ENSP00000477213

Symbol
  • FE65
  • RIR
  • RIR
  • FE65
  • MGC:9072
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.87
histone modification site profile
0.7
cellular component
0.68
hub protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.21   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.21   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
DNA Double Strand Break Response (R-HSA-5693606)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Name
Explore in Pharos
Explore in Source
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Gene Ontology Terms (42)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (121)
1 – 10 of 121
SYDE1
Tbio
Family: Enzyme
Novelty: 0.04683299
p_int: 0.999994756
p_ni: 1.25e-7
p_wrong: 0.000005119
Score: 0.182
Data Source: BioPlex,STRINGDB
APLP1
Tbio
Novelty: 0.01063681
p_int: 0.999992337
p_ni: 0.000007141
p_wrong: 5.21e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
NEURL4
Tdark
Novelty: 0.20430708
p_int: 0.999958715
p_ni: 0.000041285
Score: 0.183
Data Source: BioPlex,STRINGDB
APLP2
Tbio
Novelty: 0.0082936
p_int: 0.999758251
p_ni: 0.000241749
Score: 0.982
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00008964
p_int: 0.999297512
p_ni: 0.000702488
Score: 0.999
Data Source: BioPlex,STRINGDB
HERC2
Tbio
Family: Enzyme
Novelty: 0.06552683
p_int: 0.997943421
p_ni: 0.002056579
Data Source: BioPlex
APBB2
Tbio
Novelty: 0.06546724
p_int: 0.997922746
p_ni: 0.002077235
p_wrong: 1.9e-8
Score: 0.793
Data Source: BioPlex,STRINGDB
QTRT1
Tbio
Family: Enzyme
Novelty: 0.04387363
p_int: 0.985128024
p_ni: 0.01487197
p_wrong: 6e-9
Score: 0.748
Data Source: BioPlex,STRINGDB
DCAKD
Tdark
Family: Enzyme
Novelty: 1.5418995
p_int: 0.931182306
p_ni: 0.068817694
Score: 0.175
Data Source: BioPlex,STRINGDB
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.929936293
p_ni: 0.070063596
p_wrong: 1.11e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  158.21

PubMed score by year
PubTator Score  112.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer