Tbio RHOD Rho-related GTP-binding protein RhoD

Protein Summary

Description

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O00212

Gene Name

• RHOD

Ensembl ID

• ENST00000308831
• ENSP00000308576
• ENSG00000173156

Symbol

• ARHD
• Rho
• ARHD
• RHOM
• RHOHP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
virus perturbation	0.83
cell type or tissue	0.75
disease perturbation	0.74
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhod

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhod

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.75   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.75   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0