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Tbio
RHOD
Rho-related GTP-binding protein RhoD

Protein Summary
Description
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308831
  • ENSP00000308576
  • ENSG00000173156

Symbol
  • ARHD
  • Rho
  • ARHD
  • RHOM
  • RHOHP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
virus perturbation
0.83
cell type or tissue
0.75
disease perturbation
0.74
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.28   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.28   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat distribution
2
1
4
81.5
red blood cell density measurement
1
1
1
79.9
body height
3
2
3
74.7
heel bone mineral density
2
1
2
74.4
BMI-adjusted hip circumference
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat distribution
4
81.5
red blood cell density measurement
1
79.9
body height
3
74.7
heel bone mineral density
2
74.4
BMI-adjusted hip circumference
1
62.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member D
VGNC:1024
451358
Macaque
ras homolog family member D
712969
Mouse
MGI:108446
11854
Rat
RGD:1310985
293660
Dog
ras homolog family member D
VGNC:45558
611862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member D
Macaque
ras homolog family member D
Mouse
Rat
Dog
ras homolog family member D
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00212-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Formins
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (27)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (288)
1 – 10 of 288
C1orf198
Tdark
Novelty:  3.89427313
p_int:  0.999995402
p_ni:  0.000004598
Score:  0.28
Data Source:  BioPlex,STRINGDB
SPTB
Tbio
Novelty:  0.00467504
p_int:  0.999904789
p_ni:  0.000062578
p_wrong:  0.000032633
Score:  0.261
Data Source:  BioPlex,STRINGDB
DAAM1
Tbio
Novelty:  0.02143008
p_int:  0.999763728
p_ni:  0.000236272
Score:  0.614
Data Source:  BioPlex,STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
p_int:  0.999682679
p_ni:  0.000317321
Score:  0.478
Data Source:  BioPlex,STRINGDB
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.995188355
p_ni:  0.004811645
Score:  0.179
Data Source:  BioPlex,STRINGDB
CETN3
Tbio
Novelty:  0.00705513
p_int:  0.980116139
p_ni:  0.019883855
p_wrong:  6e-9
Score:  0.244
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.956702211
p_ni:  0.030998484
p_wrong:  0.012299305
Score:  0.207
Data Source:  BioPlex,STRINGDB
DIAPH1
Tbio
Novelty:  0.0150259
p_int:  0.794447261
p_ni:  0.205552739
Score:  0.672
Data Source:  BioPlex,STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.978
Data Source:  STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.974
Data Source:  STRINGDB
Publication Statistics
PubMed Score  286.28

PubMed score by year
PubTator Score  25.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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