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Tchem
TLR4
Toll-like receptor 4

Protein Summary
Description
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internaliz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355622
  • ENSP00000363089
  • ENSG00000136869
  • ENST00000394487
  • ENSP00000377997
  • ENST00000645071
  • ENSP00000494590

Symbol
  • TOLL
  • CD284
  • TLR-4
  • ARMD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.97
protein domain
0.92
disease
0.86
phenotype
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12417.52   (req: < 5)
Gene RIFs: 1908   (req: <= 3)
Antibodies: 1695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12417.52   (req: >= 5)
Gene RIFs: 1908   (req: > 3)
Antibodies: 1695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 87
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1