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Tbio
SULT2B1
Sulfotransferase family cytosolic 2B member 1

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201586
  • ENSP00000201586
  • ENSG00000088002
  • ENST00000323090
  • ENSP00000312880

Symbol
  • HSST2
  • HSST2
  • ARCI14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
cell type or tissue
0.71
disease
0.68
small molecule perturbation
0.68
gene perturbation
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.25   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.25   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfotransferase family 2B member 1
VGNC:2238
747360
Macaque
sulfotransferase family 2B member 1
718739
Mouse
MGI:1926342
54200
Rat
RGD:1308882
292915
Dog
sulfotransferase family 2B member 1
VGNC:46979
484403
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfotransferase family 2B member 1
Macaque
sulfotransferase family 2B member 1
Mouse
Rat
Dog
sulfotransferase family 2B member 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00204-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (105)
1 – 10 of 105
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.999978021
p_ni: 0.000021973
p_wrong: 6e-9
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.99995012
p_ni: 0.000032238
p_wrong: 0.000017643
Score: 0.335
Data Source: BioPlex,STRINGDB
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.999936692
p_ni: 0.000063258
p_wrong: 5e-8
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.999920972
p_ni: 0.000079012
p_wrong: 1.6e-8
Data Source: BioPlex
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.999784212
p_ni: 0.000213569
p_wrong: 0.00000222
Data Source: BioPlex
GMCL1
Tbio
Novelty: 0.1543762
p_int: 0.998463226
p_ni: 0.000521841
p_wrong: 0.001014934
Score: 0.205
Data Source: BioPlex,STRINGDB
STS
Tchem
Family: Enzyme
Novelty: 0.00324549
Score: 0.943
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.939
Data Source: STRINGDB
CYP7A1
Tbio
Family: Enzyme
Novelty: 0.00148194
Score: 0.928
Data Source: STRINGDB
CYP11A1
Tclin
Family: Enzyme
Novelty: 0.00096368
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.25

PubMed score by year
PubTator Score  41.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer