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Tbio
AP3B1
AP-3 complex subunit beta-1

Protein Summary
Description
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255194
  • ENSP00000255194
  • ENSG00000132842
  • ENST00000519295
  • ENSP00000430597

Symbol
  • ADTB3A
  • PE
  • HPS
  • HPS2
  • ADTB3
  • ADTB3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
transcription factor binding site profile
0.93
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.12   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.12   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
4
1
25
79.3
BMI-adjusted hip circumference
1
1
1
62.6
alkaline phosphatase measurement
2
1
1
5.5
57.8
platelet crit
1
1
1
54.4
comparative body size at age 10, self-reported
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
25
79.3
BMI-adjusted hip circumference
1
62.6
alkaline phosphatase measurement
1
5.5
57.8
platelet crit
1
54.4
comparative body size at age 10, self-reported
1
47.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit beta 1
VGNC:6378
461789
Macaque
adaptor related protein complex 3 beta 1 subunit
708754
Mouse
MGI:1333879
11774
Rat
RGD:1310256
309969
Dog
adaptor related protein complex 3 subunit beta 1
VGNC:37963
403459
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit beta 1
Macaque
adaptor related protein complex 3 beta 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 3 subunit beta 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00203-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Oncogenic MAPK signaling
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Oncogenic MAPK signaling
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (239)
1 – 10 of 239
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.999999924
p_ni:  7.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
AP3M1
Tbio
Novelty:  0.5036622
p_int:  0.999999797
p_ni:  2.03e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999998888
p_ni:  0.000001112
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.999951852
p_ni:  0.000048148
Data Source:  BioPlex
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999920101
p_ni:  0.000079899
Score:  0.157
Data Source:  BioPlex,STRINGDB
AP3M2
Tbio
Novelty:  0.18164255
p_int:  0.999905302
p_ni:  0.000094698
Score:  0.986
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999378575
p_ni:  0.000621425
Score:  0.375
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.99869772
p_ni:  0.00130228
Score:  0.952
Data Source:  BioPlex,STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.99860298
p_ni:  0.00139702
Data Source:  BioPlex
NHLH2
Tbio
Family:  TF
Novelty:  0.04744703
p_int:  0.998125048
p_ni:  0.001874952
Data Source:  BioPlex
Publication Statistics
PubMed Score  34.12

PubMed score by year
PubTator Score  26.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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